Expasy logo

ENZYME

ENZYME entry: EC 2.5.1.59

Accepted Name
protein geranylgeranyltransferase type I
Alternative Name(s)
GGTaseI
GGTase-I
type I protein geranyl-geranyltransferase
Reaction catalysed
geranylgeranyl diphosphate + L-cysteinyl-[protein] <=> diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]
Comment(s)
  • This enzyme, along with EC 2.5.1.58 and EC 2.5.1.60, constitutes the protein prenyltransferase family of enzymes.
  • Catalyzes the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein.
  • These protein acceptors have the C-terminal sequence CA(1)A(2)X, where the terminal residue, X, is preferably leucine; serine, methionine, alanine or glutamine makes the protein a substrate for EC 2.5.1.58.
  • The enzymes are relaxed in specificity for A(1), but cannot act if A(2) is aromatic.
  • Known targets of this enzyme include most gamma-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
  • The Zn(2+) is required for peptide, but not for isoprenoid, substrate binding.
Cross-references
BRENDA2.5.1.59
EC2PDB2.5.1.59
ExplorEnz2.5.1.59
PRIAM enzyme-specific profiles2.5.1.59
KEGG Ligand Database for Enzyme Nomenclature2.5.1.59
IUBMB Enzyme Nomenclature2.5.1.59
IntEnz2.5.1.59
MEDLINEFind literature relating to 2.5.1.59
MetaCyc2.5.1.59
Rhea expert-curated reactions2.5.1.59
UniProtKB/Swiss-Prot
Q9LX33, FNTA_ARATHP29702, FNTA_BOVINQ9Y765, FNTA_CANAX
Q54RT9, FNTA_DICDIP49354, FNTA_HUMANQ61239, FNTA_MOUSE
O24304, FNTA_PEAQ04631, FNTA_RATO60052, FNTA_SCHPO
P93227, FNTA_SOLLCP29703, FNTA_YEASTO80642, PGTB1_ARATH
Q5EAD5, PGTB1_BOVINQ55DA3, PGTB1_DICDIP53609, PGTB1_HUMAN
Q8BUY9, PGTB1_MOUSEP53610, PGTB1_RATP32434, PGTB1_SCHPO
P18898, PGTB1_YEAST

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-