ENZYME entry: EC 1.1.1.1

Accepted Name
Alcohol dehydrogenase.
Alternative Name(s)
Aldehyde reductase.
Reaction catalysed
  • An alcohol + NAD(+) <=> an aldehyde or ketone + NADH
  • A secondary alcohol + NAD(+) <=> a ketone + NADH
Cofactor(s)
Zn(2+) or Fe cation.
Comment(s)
  • Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol.
  • The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
Cross-references
PROSITEPDOC00058 ; PDOC00059 ; PDOC00060
BRENDA1.1.1.1
EC2PDB1.1.1.1
ExplorEnz1.1.1.1
PRIAM enzyme-specific profiles1.1.1.1
KEGG Ligand Database for Enzyme Nomenclature1.1.1.1
IUBMB Enzyme Nomenclature1.1.1.1
IntEnz1.1.1.1
MEDLINEFind literature relating to 1.1.1.1
MetaCyc1.1.1.1
UniProtKB/Swiss-Prot
P07327, ADH1A_HUMAN;  P28469, ADH1A_MACMU;  Q5RBP7, ADH1A_PONAB;  
P25405, ADH1A_SAAHA;  P00325, ADH1B_HUMAN;  Q5R1W2, ADH1B_PANTR;  
P14139, ADH1B_PAPHA;  P25406, ADH1B_SAAHA;  P00327, ADH1E_HORSE;  
P00326, ADH1G_HUMAN;  O97959, ADH1G_PAPHA;  P00328, ADH1S_HORSE;  
P80222, ADH1_ALLMI;  P30350, ADH1_ANAPL;  P49645, ADH1_APTAU;  
P06525, ADH1_ARATH;  P41747, ADH1_ASPFN;  Q17334, ADH1_CAEEL;  
P43067, ADH1_CANAX;  P85440, ADH1_CATRO;  P48814, ADH1_CERCA;  
Q70UN9, ADH1_CERCO;  P23991, ADH1_CHICK;  P86883, ADH1_COLLI;  
P19631, ADH1_COTJA;  P23236, ADH1_DROHY;  P48586, ADH1_DROMN;  
P09370, ADH1_DROMO;  P22246, ADH1_DROMT;  P07161, ADH1_DROMU;  
P12854, ADH1_DRONA;  P08843, ADH1_EMENI;  P26325, ADH1_GADMC;  
Q9Z2M2, ADH1_GEOAT;  Q64413, ADH1_GEOBU;  Q64415, ADH1_GEOKN;  
P12311, ADH1_GEOSE;  P05336, ADH1_HORVU;  P20369, ADH1_KLULA;  
Q07288, ADH1_KLUMA;  P00333, ADH1_MAIZE;  P86885, ADH1_MESAU;  
P00329, ADH1_MOUSE;  P80512, ADH1_NAJNA;  Q9P6C8, ADH1_NEUCR;  
Q75ZX4, ADH1_ORYSI;  Q2R8Z5, ADH1_ORYSJ;  P12886, ADH1_PEA;  
P22797, ADH1_PELPE;  P14219, ADH1_PENAM;  P41680, ADH1_PERMA;  
P25141, ADH1_PETHY;  O00097, ADH1_PICST;  Q03505, ADH1_RABIT;  
P06757, ADH1_RAT;  P14673, ADH1_SOLTU;  P80338, ADH1_STRCA;  
P13603, ADH1_TRIRP;  P00330, ADH1_YEAST;  Q07264, ADH1_ZEALU;  
P20368, ADH1_ZYMMO;  O45687, ADH2_CAEEL;  O94038, ADH2_CANAL;  
P48815, ADH2_CERCA;  Q70UP5, ADH2_CERCO;  Q70UP6, ADH2_CERRO;  
P27581, ADH2_DROAR;  P25720, ADH2_DROBU;  P23237, ADH2_DROHY;  
P48587, ADH2_DROMN;  P09369, ADH2_DROMO;  P07160, ADH2_DROMU;  
P24267, ADH2_DROWH;  P37686, ADH2_ECOLI;  P54202, ADH2_EMENI;  
Q24803, ADH2_ENTHI;  P42327, ADH2_GEOSE;  P10847, ADH2_HORVU;  
P49383, ADH2_KLULA;  Q9P4C2, ADH2_KLUMA;  P04707, ADH2_MAIZE;  
Q4R1E8, ADH2_ORYSI;  Q0ITW7, ADH2_ORYSJ;  O13309, ADH2_PICST;  
P28032, ADH2_SOLLC;  P14674, ADH2_SOLTU;  F2Z678, ADH2_YARLI;  
P00331, ADH2_YEAST;  F8DVL8, ADH2_ZYMMA;  P0DJA2, ADH2_ZYMMO;  
P07754, ADH3_EMENI;  P42328, ADH3_GEOSE;  P10848, ADH3_HORVU;  
P49384, ADH3_KLULA;  P14675, ADH3_SOLTU;  P07246, ADH3_YEAST;  
P08319, ADH4_HUMAN;  P49385, ADH4_KLULA;  Q9QYY9, ADH4_MOUSE;  
Q64563, ADH4_RAT;  Q09669, ADH4_SCHPO;  P80468, ADH4_STRCA;  
A6ZTT5, ADH4_YEAS7;  P10127, ADH4_YEAST;  Q6XQ67, ADH5_SACPS;  
P38113, ADH5_YEAST;  P28332, ADH6_HUMAN;  P41681, ADH6_PERMA;  
Q5R7Z8, ADH6_PONAB;  Q5XI95, ADH6_RAT;  P40394, ADH7_HUMAN;  
Q64437, ADH7_MOUSE;  P41682, ADH7_RAT;  P9WQC0, ADHA_MYCTO;  
P9WQC1, ADHA_MYCTU;  O31186, ADHA_RHIME;  Q7U1B9, ADHB_MYCBO;  
P9WQC6, ADHB_MYCTO;  P9WQC7, ADHB_MYCTU;  P9WQB8, ADHD_MYCTO;  
P9WQB9, ADHD_MYCTU;  P33744, ADHE_CLOAB;  P0A9Q8, ADHE_ECO57;  
P0A9Q7, ADHE_ECOLI;  P81600, ADHH_GADMO;  P72324, ADHI_RHOS4;  
Q9SK86, ADHL1_ARATH;  Q9SK87, ADHL2_ARATH;  A1L4Y2, ADHL3_ARATH;  
Q8VZ49, ADHL4_ARATH;  Q0V7W6, ADHL5_ARATH;  Q8LEB2, ADHL6_ARATH;  
Q9FH04, ADHL7_ARATH;  P81601, ADHL_GADMO;  P39451, ADHP_ECOLI;  
O46649, ADHP_RABIT;  O46650, ADHQ_RABIT;  Q96533, ADHX_ARATH;  
Q3ZC42, ADHX_BOVIN;  Q17335, ADHX_CAEEL;  Q54TC2, ADHX_DICDI;  
P46415, ADHX_DROME;  P19854, ADHX_HORSE;  P11766, ADHX_HUMAN;  
P93629, ADHX_MAIZE;  P28474, ADHX_MOUSE;  P80360, ADHX_MYXGL;  
P81431, ADHX_OCTVU;  A2XAZ3, ADHX_ORYSI;  Q0DWH1, ADHX_ORYSJ;  
P80572, ADHX_PEA;  O19053, ADHX_RABIT;  P12711, ADHX_RAT;  
P80467, ADHX_SAAHA;  P86884, ADHX_SCYCA;  P79896, ADHX_SPAAU;  
Q9NAR7, ADH_BACOL;  P14940, ADH_CUPNE;  Q0KDL6, ADH_CUPNH;  
Q00669, ADH_DROAD;  P21518, ADH_DROAF;  P25139, ADH_DROAM;  
Q50L96, ADH_DROAN;  P48584, ADH_DROBO;  P22245, ADH_DRODI;  
Q9NG42, ADH_DROEQ;  P28483, ADH_DROER;  P48585, ADH_DROFL;  
P51551, ADH_DROGR;  Q09009, ADH_DROGU;  P51549, ADH_DROHA;  
P21898, ADH_DROHE;  Q07588, ADH_DROIM;  Q9NG40, ADH_DROIN;  
Q27404, ADH_DROLA;  P10807, ADH_DROLE;  P07162, ADH_DROMA;  
Q09010, ADH_DROMD;  P00334, ADH_DROME;  Q00671, ADH_DROMM;  
P25721, ADH_DROMY;  Q00672, ADH_DRONI;  P07159, ADH_DROOR;  
P84328, ADH_DROPB;  P37473, ADH_DROPE;  P23361, ADH_DROPI;  
P23277, ADH_DROPL;  Q6LCE4, ADH_DROPS;  Q9U8S9, ADH_DROPU;  
Q9GN94, ADH_DROSE;  Q24641, ADH_DROSI;  P23278, ADH_DROSL;  
Q03384, ADH_DROSU;  P28484, ADH_DROTE;  P51550, ADH_DROTS;  
B4M8Y0, ADH_DROVI;  Q05114, ADH_DROWI;  P26719, ADH_DROYA;  
P17648, ADH_FRAAN;  P48977, ADH_MALDO;  P81786, ADH_MORSE;  
P9WQC2, ADH_MYCTO;  P9WQC3, ADH_MYCTU;  P25988, ADH_SCAAL;  
Q00670, ADH_SCACA;  P00332, ADH_SCHPO;  Q2FJ31, ADH_STAA3;  
Q2G0G1, ADH_STAA8;  Q2YSX0, ADH_STAAB;  Q5HI63, ADH_STAAC;  
Q99W07, ADH_STAAM;  Q7A742, ADH_STAAN;  Q6GJ63, ADH_STAAR;  
Q6GBM4, ADH_STAAS;  Q8NXU1, ADH_STAAW;  Q5HRD6, ADH_STAEQ;  
Q8CQ56, ADH_STAES;  Q4J781, ADH_SULAC;  P39462, ADH_SULSO;  
P50381, ADH_SULSR;  Q96XE0, ADH_SULTO;  P51552, ADH_ZAPTU;  
P32771, FADH_YEAST;  A7ZIA4, FRMA_ECO24;  Q8X5J4, FRMA_ECO57;  
A7ZX04, FRMA_ECOHS;  A1A835, FRMA_ECOK1;  Q0TKS7, FRMA_ECOL5;  
Q8FKG1, FRMA_ECOL6;  B1J085, FRMA_ECOLC;  P25437, FRMA_ECOLI;  
B1LIP1, FRMA_ECOSM;  Q1RFI7, FRMA_ECOUT;  P44557, FRMA_HAEIN;  
P39450, FRMA_PHODP;  Q3Z550, FRMA_SHISS;  P73138, FRMA_SYNY3;  
P71017, GBSB_BACSU;  A1CFL1, PATD_ASPCL;  P33010, TERPD_PSESP;  
O07737, Y1895_MYCTU;  

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