ENZYME entry: EC 1.1.1.103

Accepted Name
L-threonine 3-dehydrogenase.
Alternative Name(s)
TDH.
Reaction catalysed
L-threonine + NAD(+) <=> L-2-amino-3-oxobutanoate + NADH
Comment(s)
  • Acts in concert with EC 2.3.1.29 in the degradation of threonine to glycine.
  • This threonine-degradation pathway is common to prokaryotic and eukaryotic cells and the two enzymes involved form a complex.
  • In aqueous solution, the product L-2-amino-3-oxobutanoate can spontaneously decarboxylate to form aminoacetone.
Cross-references
PROSITEPDOC00058
BRENDA1.1.1.103
EC2PDB1.1.1.103
ExplorEnz1.1.1.103
PRIAM enzyme-specific profiles1.1.1.103
KEGG Ligand Database for Enzyme Nomenclature1.1.1.103
IUBMB Enzyme Nomenclature1.1.1.103
IntEnz1.1.1.103
MEDLINEFind literature relating to 1.1.1.103
MetaCyc1.1.1.103
UniProtKB/Swiss-Prot
A0KQV6, TDH_AERHH;  A4SHB7, TDH_AERS4;  B9J738, TDH_AGRRK;  
B6ESA4, TDH_ALISL;  B4S298, TDH_ALTMD;  B8J714, TDH_ANAD2;  
Q2IJN4, TDH_ANADE;  A7HEI5, TDH_ANADF;  B4UMJ1, TDH_ANASK;  
A7Z4X0, TDH_BACA2;  Q65JE7, TDH_BACLD;  O31776, TDH_BACSU;  
Q2KIR8, TDH_BOVIN;  B1YXP0, TDH_BURA4;  Q1BK24, TDH_BURCA;  
B1K269, TDH_BURCC;  A0B459, TDH_BURCH;  B4EFZ7, TDH_BURCJ;  
Q0B5Q1, TDH_BURCM;  A9AR24, TDH_BURM1;  A3MAC8, TDH_BURM7;  
A2RZW5, TDH_BURM9;  Q62EL5, TDH_BURMA;  A1UXP8, TDH_BURMS;  
A3P139, TDH_BURP0;  Q3JID4, TDH_BURP1;  A3NF91, TDH_BURP6;  
B2JPU0, TDH_BURP8;  B2T7X5, TDH_BURPP;  Q63PD9, TDH_BURPS;  
Q38ZS8, TDH_BURS3;  Q2T9E1, TDH_BURTA;  A4JKG7, TDH_BURVG;  
Q13SG2, TDH_BURXL;  Q11L77, TDH_CHESB;  Q7NXH5, TDH_CHRVO;  
A8ARK6, TDH_CITK8;  Q48AM4, TDH_COLP3;  B6J2S1, TDH_COXB2;  
A9KET6, TDH_COXBN;  A9NA21, TDH_COXBR;  Q83F39, TDH_COXBU;  
A7MID0, TDH_CROS8;  C1D195, TDH_DEIDV;  Q9RTU4, TDH_DEIRA;  
A7ZTH0, TDH_ECO24;  B7ULH2, TDH_ECO27;  B7MFI0, TDH_ECO45;  
B7L742, TDH_ECO55;  Q8XEJ1, TDH_ECO57;  B5YWB7, TDH_ECO5E;  
B7NPC5, TDH_ECO7I;  B7N1S0, TDH_ECO81;  B7M4A3, TDH_ECO8A;  
C4ZXK8, TDH_ECOBW;  B1X950, TDH_ECODH;  A8A681, TDH_ECOHS;  
A1AHF3, TDH_ECOK1;  Q0TBJ0, TDH_ECOL5;  Q8FCA2, TDH_ECOL6;  
B1IZH4, TDH_ECOLC;  P07913, TDH_ECOLI;  B7NES3, TDH_ECOLU;  
B6I3J6, TDH_ECOSE;  B1LK55, TDH_ECOSM;  Q1R4X4, TDH_ECOUT;  
C5BB99, TDH_EDWI9;  A4W529, TDH_ENT38;  B7LVH6, TDH_ESCF3;  
B0TYR8, TDH_FRAP2;  Q14IB6, TDH_FRAT1;  A7NDM9, TDH_FRATF;  
Q2A282, TDH_FRATH;  B2SDJ2, TDH_FRATM;  A0Q5K3, TDH_FRATN;  
Q0BKV5, TDH_FRATO;  Q5NGW4, TDH_FRATT;  A4IZ92, TDH_FRATW;  
Q5QUN8, TDH_IDILO;  B5XTI4, TDH_KLEP3;  A6TFL2, TDH_KLEP7;  
Q5X748, TDH_LEGPA;  A5IGK7, TDH_LEGPC;  Q5ZXM9, TDH_LEGPH;  
Q5WYJ7, TDH_LEGPL;  A6W1W3, TDH_MARMS;  Q8K3F7, TDH_MOUSE;  
Q6MD15, TDH_PARUW;  Q6DAT5, TDH_PECAS;  C6DIA7, TDH_PECCP;  
Q7MY48, TDH_PHOLL;  Q6LRD9, TDH_PHOPR;  Q8MIR0, TDH_PIG;  
Q6AAR3, TDH_PROAC;  B4F134, TDH_PROMH;  Q15ZU4, TDH_PSEA6;  
Q3IHW0, TDH_PSEHT;  A1SVW5, TDH_PSYIN;  Q9UYX0, TDH_PYRAB;  
Q8U259, TDH_PYRFU;  O58389, TDH_PYRHO;  B3PUI4, TDH_RHIE6;  
Q2K618, TDH_RHIEC;  Q1MDT5, TDH_RHIL3;  Q983J7, TDH_RHILO;  
B5ZXE7, TDH_RHILW;  Q52998, TDH_RHIME;  C3MFH1, TDH_RHISN;  
Q5LN53, TDH_RUEPO;  A4FND4, TDH_SACEN;  B5EXC3, TDH_SALA4;  
A9MKQ8, TDH_SALAR;  Q57IC5, TDH_SALCH;  B5FLI6, TDH_SALDC;  
B5R5E1, TDH_SALEP;  B5RGH0, TDH_SALG2;  B4T9A1, TDH_SALHS;  
B4SXB9, TDH_SALNS;  Q5PC07, TDH_SALPA;  A9MVL0, TDH_SALPB;  
C0Q1V0, TDH_SALPC;  B5BHZ1, TDH_SALPK;  B4TZV9, TDH_SALSV;  
Q8Z2F4, TDH_SALTI;  Q8ZL52, TDH_SALTY;  A8GLC6, TDH_SERP5;  
A1S1Q3, TDH_SHEAM;  B8EDS6, TDH_SHEB2;  A3CYN0, TDH_SHEB5;  
A6WUG6, TDH_SHEB8;  A9KWY0, TDH_SHEB9;  Q07W50, TDH_SHEFN;  
B0TNM4, TDH_SHEHH;  A3QJC8, TDH_SHELP;  Q8E8J1, TDH_SHEON;  
A8GYP8, TDH_SHEPA;  A4YCC5, TDH_SHEPC;  A0L2Q3, TDH_SHESA;  
A8FPE0, TDH_SHESH;  Q0HDA3, TDH_SHESM;  Q0HPI5, TDH_SHESR;  
A1RE07, TDH_SHESW;  B1KL24, TDH_SHEWM;  B2U5D5, TDH_SHIB3;  
Q31V06, TDH_SHIBS;  Q329N8, TDH_SHIDS;  Q0SYE5, TDH_SHIF8;  
P59409, TDH_SHIFL;  Q3YVY1, TDH_SHISS;  A6UBM6, TDH_SINMW;  
Q02BT1, TDH_SOLUE;  Q82MN2, TDH_STRAW;  Q9L233, TDH_STRCO;  
B1VWE7, TDH_STRGG;  B2FQN4, TDH_STRMK;  Q67N85, TDH_SYMTH;  
Q5JI69, TDH_THEKO;  B6YTJ5, TDH_THEON;  Q72L62, TDH_THET2;  
Q5SKS4, TDH_THET8;  Q8R7K0, TDH_THETN;  A5F0N6, TDH_VIBC3;  
Q9KL62, TDH_VIBCH;  C3LWF0, TDH_VIBCM;  Q5E0F9, TDH_VIBF1;  
B5ETJ6, TDH_VIBFM;  P59410, TDH_VIBPA;  B7VR52, TDH_VIBSL;  
Q8D442, TDH_VIBVU;  Q7MFL5, TDH_VIBVY;  Q8PNN2, TDH_XANAC;  
Q3BWT0, TDH_XANC5;  Q4URI9, TDH_XANC8;  B0RU31, TDH_XANCB;  
O34268, TDH_XANCP;  Q2NZP2, TDH_XANOM;  Q5GWI3, TDH_XANOR;  
A1JHX8, TDH_YERE8;  A7FCU5, TDH_YERP3;  Q1C278, TDH_YERPA;  
B2JYP4, TDH_YERPB;  Q8ZJN2, TDH_YERPE;  A9R685, TDH_YERPG;  
Q1CD13, TDH_YERPN;  A4TSC6, TDH_YERPP;  Q66GC5, TDH_YERPS;  
B1JQW2, TDH_YERPY;  

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