ID   1.1.1.105
DE   all-trans-retinol dehydrogenase (NAD(+)).
CA   all-trans-retinol--[retinol-binding protein] + NAD(+) = all-trans-
CA   retinal--[retinol-binding protein] + H(+) + NADH.
CC   -!- The enzyme recognizes all-trans-retinol and all-trans-retinal as
CC       substrates and exhibits a strong preference for NAD(+)/NADH as
CC       cofactors.
CC   -!- Recognizes the substrate both in free form and when bound to
CC       cellular-retinol-binding-protein (CRBP1), but has higher affinity for
CC       the bound form.
CC   -!- No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315).
CC   -!- Also active with 3alpha-hydroxysteroids.
DR   P00325, ADH1B_HUMAN;  Q5R1W2, ADH1B_PANTR;  P14139, ADH1B_PAPHA;
DR   P08319, ADH4_HUMAN ;  Q9QYY9, ADH4_MOUSE ;  Q64563, ADH4_RAT   ;
DR   P80468, ADH4_STRCA ;  P40394, ADH7_HUMAN ;  Q64437, ADH7_MOUSE ;
DR   P41682, ADH7_RAT   ;  Q7Z5P4, DHB13_HUMAN;  Q8VCR2, DHB13_MOUSE;
DR   Q5M875, DHB13_RAT  ;  Q8HYR6, DHRS9_BOVIN;  Q9BPW9, DHRS9_HUMAN;
DR   Q58NB6, DHRS9_MOUSE;  Q8VD48, DHRS9_RAT  ;  Q1RMJ5, DRS7C_BOVIN;
DR   A6NNS2, DRS7C_HUMAN;  Q8CHS7, DRS7C_MOUSE;  D3ZGP9, DRS7C_RAT  ;
DR   Q3T001, H17B6_BOVIN;  O14756, H17B6_HUMAN;  Q9R092, H17B6_MOUSE;
DR   O54753, H17B6_RAT  ;  O75452, RDH16_HUMAN;  O54909, RDH16_MOUSE;
DR   P50170, RDH16_RAT  ;  O88451, RDH7_MOUSE ;  P55006, RDH7_RAT   ;
DR   Q8N3Y7, RDHE2_HUMAN;  Q7TQA3, RDHE2_MOUSE;
//