ID   1.1.1.105
DE   All-trans-retinol dehydrogenase (NAD(+)).
CA   All-trans-retinol-[cellular-retinol-binding-protein] + NAD(+) = all-
CA   trans-retinal-[cellular-retinol-binding-protein] + NADH.
CC   -!- The enzyme recognizes all-trans-retinol and all-trans-retinal as
CC       substrates and exhibits a strong preference for NAD(+)/NADH as
CC       cofactors.
CC   -!- Recognizes the substrate both in free form and when bound to
CC       cellular-retinol-binding-protein (CRBP1), but has higher affinity for
CC       the bound form.
CC   -!- No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315).
CC   -!- Also active with 3-alpha-hydroxysteroids.
PR   PROSITE; PDOC00060;
DR   Q3T001, H17B6_BOVIN;  O14756, H17B6_HUMAN;  Q9R092, H17B6_MOUSE;
DR   O54753, H17B6_RAT  ;  P50170, RDH2_RAT   ;  P50169, RDH3_RAT   ;
DR   O88451, RDH7_MOUSE ;  P55006, RDH7_RAT   ;  Q8N3Y7, RDHE2_HUMAN;
DR   Q7TQA3, RDHE2_MOUSE;
//