ID   1.1.1.153
DE   sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming).
CA   (1) L-erythro-7,8-dihydrobiopterin + NADP(+) = H(+) + NADPH +
CA   sepiapterin.
CA   (2) (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-
CA   5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH.
CC   -!- This enzyme catalyzes the final step in the de novo synthesis of
CC       tetrahydrobiopterin from GTP.
CC   -!- The enzyme, which is found in higher animals and some fungi and
CC       bacteria, produces the erythro form of tetrahydrobiopterin. cf.
CC       EC 1.1.1.325.
DR   Q17QK8, SPRE_BOVIN ;  Q54GP3, SPRE_DICDI ;  P35270, SPRE_HUMAN ;
DR   Q8R536, SPRE_MERUN ;  Q64105, SPRE_MOUSE ;  P18297, SPRE_RAT   ;
DR   Q7ZY31, SPRE_XENLA ;  B0BML7, SPRE_XENTR ;
//