ID 1.1.1.159 DE 7-alpha-hydroxysteroid dehydrogenase. CA 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + NAD(+) = CA 3-alpha,12-alpha-dihydroxy-7-oxo-5-beta-cholanate + NADH. CC -!- Catalyzes the oxidation of the 7-alpha-hydroxy group of bile acids CC and alcohols both in their free and conjugated forms. CC -!- The Bacteroides fragilis and Clostridium enzymes can also utilize CC NADP(+). PR PROSITE; PDOC00060; DR P0AET9, HDHA_ECO57 ; P0AET8, HDHA_ECOLI ; //