ID 1.1.1.159 DE 7alpha-hydroxysteroid dehydrogenase. CA cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) CA + NADH. CC -!- Catalyzes the oxidation of the 7alpha-hydroxy group of bile acids and CC alcohols both in their free and conjugated forms. CC -!- The Bacteroides fragilis and Clostridium enzymes can also utilize CC NADP(+). DR O02691, HCD2_BOVIN ; Q99714, HCD2_HUMAN ; O08756, HCD2_MOUSE ; DR O70351, HCD2_RAT ; Q5LA59, HDHA_BACFN ; P0AET9, HDHA_ECO57 ; DR P0AET8, HDHA_ECOLI ; //