ID 1.1.1.176 DE 12alpha-hydroxysteroid dehydrogenase. CA cholate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) CA + NADPH. CC -!- Catalyzes the oxidation of the 12alpha-hydroxy group of bile acids, CC both in their free and conjugated form. CC -!- Also acts on bile alcohols. DR P21215, 12AH_CLOS4 ; //