ENZYME entry: EC 1.1.1.267

Accepted Name
1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Alternative Name(s)
1-deoxyxylulose-5-phosphate reductoisomerase.
DXP-reductoisomerase.
Reaction catalysed
2-C-methyl-D-erythritol 4-phosphate + NADP(+) <=> 1-deoxy-D-xylulose 5-phosphate + NADPH
Cofactor(s)
Mg(2+) or cobalt cation or Mn(2+).
Comment(s)
  • The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.
  • The mechanism has been shown to be a retroaldol/aldol reaction.
Cross-references
BRENDA1.1.1.267
EC2PDB1.1.1.267
ExplorEnz1.1.1.267
PRIAM enzyme-specific profiles1.1.1.267
KEGG Ligand Database for Enzyme Nomenclature1.1.1.267
IUBMB Enzyme Nomenclature1.1.1.267
IntEnz1.1.1.267
MEDLINEFind literature relating to 1.1.1.267
MetaCyc1.1.1.267
UniProtKB/Swiss-Prot
Q81N10, DXR1_BACAN;  Q81B49, DXR1_BACCR;  Q638M6, DXR1_BACCZ;  
Q6HG59, DXR1_BACHK;  Q81WL4, DXR2_BACAN;  Q819Y3, DXR2_BACCR;  
Q636K5, DXR2_BACCZ;  Q6HEZ4, DXR2_BACHK;  B0CD21, DXR_ACAM1;  
Q6FCG9, DXR_ACIAD;  B7H1U5, DXR_ACIB3;  B7I9U9, DXR_ACIB5;  
B2I325, DXR_ACIBC;  B0VMU8, DXR_ACIBS;  A3M654, DXR_ACIBT;  
B0V6F3, DXR_ACIBY;  B7J9P7, DXR_ACIF2;  B5EQQ4, DXR_ACIF5;  
A3MZC4, DXR_ACTP2;  B0BTR0, DXR_ACTPJ;  A0KHG9, DXR_AERHH;  
A4SQH6, DXR_AERS4;  B9JBW0, DXR_AGRRK;  Q8UC86, DXR_AGRT5;  
B9JTP4, DXR_AGRVS;  B6EK51, DXR_ALISL;  A8MHH5, DXR_ALKOO;  
B8J6S7, DXR_ANAD2;  B9KIT5, DXR_ANAMF;  Q5PAI9, DXR_ANAMM;  
Q2GKQ8, DXR_ANAPZ;  B4UD63, DXR_ANASK;  Q3MDL2, DXR_ANAVT;  
O66722, DXR_AQUAE;  Q9XFS9, DXR_ARATH;  Q5NZG9, DXR_AROAE;  
A1R4Z8, DXR_ARTAT;  B8HFR2, DXR_ARTCA;  A0JUS3, DXR_ARTS2;  
A7Z4S6, DXR_BACA2;  Q732P8, DXR_BACC1;  C1EP45, DXR_BACC3;  
B7HLF4, DXR_BACC7;  B9IVB0, DXR_BACCQ;  Q5L9P6, DXR_BACFN;  
Q64PY9, DXR_BACFR;  Q9KA69, DXR_BACHD;  Q65JJ3, DXR_BACLD;  
A8FDB9, DXR_BACP2;  Q5WFT4, DXR_BACSK;  O31753, DXR_BACSU;  
Q8A684, DXR_BACTN;  A6L0W8, DXR_BACV8;  Q1LSV3, DXR_BAUCH;  
C5BWT4, DXR_BEUC1;  B3DQ62, DXR_BIFLD;  Q8G7Y7, DXR_BIFLO;  
B7GQ02, DXR_BIFLS;  Q7VRE2, DXR_BLOFL;  Q493C8, DXR_BLOPB;  
Q2L155, DXR_BORA1;  Q7WJ88, DXR_BORBR;  Q7WA54, DXR_BORPA;  
A9INU2, DXR_BORPD;  Q7VYC4, DXR_BORPE;  Q89KP9, DXR_BRADU;  
A5EK49, DXR_BRASB;  A4YVG0, DXR_BRASO;  C0ZF60, DXR_BREBN;  
B8D932, DXR_BUCA5;  P57329, DXR_BUCAI;  Q8K9S7, DXR_BUCAP;  
B8D7D6, DXR_BUCAT;  B1YS68, DXR_BURA4;  Q1BHH6, DXR_BURCA;  
B1JUE4, DXR_BURCC;  A0K8D7, DXR_BURCH;  B4ECM5, DXR_BURCJ;  
Q0BE21, DXR_BURCM;  A9AIM0, DXR_BURM1;  A3MKT7, DXR_BURM7;  
A2SB78, DXR_BURM9;  Q62JD0, DXR_BURMA;  A1V563, DXR_BURMS;  
A3NWM5, DXR_BURP0;  Q3JR34, DXR_BURP1;  A3NAU2, DXR_BURP6;  
B2JIC0, DXR_BURP8;  B2T5I8, DXR_BURPP;  Q63T18, DXR_BURPS;  
Q39F49, DXR_BURS3;  Q2SWZ2, DXR_BURTA;  A4JF69, DXR_BURVG;  
Q13XC2, DXR_BURXL;  Q8RA28, DXR_CALS4;  A7H0K4, DXR_CAMC5;  
A0RMI1, DXR_CAMFF;  A7HZP3, DXR_CAMHC;  A8FN24, DXR_CAMJ8;  
A7H243, DXR_CAMJD;  Q9PMV3, DXR_CAMJE;  A1W0W2, DXR_CAMJJ;  
Q5HT65, DXR_CAMJR;  B9KE50, DXR_CAMLR;  Q3AB86, DXR_CARHZ;  
B8GWR7, DXR_CAUCN;  Q9A709, DXR_CAUCR;  B3PBQ4, DXR_CELJU;  
Q5L651, DXR_CHLAB;  Q3AUE4, DXR_CHLCH;  Q823G9, DXR_CHLCV;  
Q254F0, DXR_CHLFF;  B3EE57, DXR_CHLL2;  Q9PKW8, DXR_CHLMU;  
B3EK13, DXR_CHLPB;  A1BJT7, DXR_CHLPD;  Q9Z8J8, DXR_CHLPN;  
B0B9H9, DXR_CHLT2;  B3QXY0, DXR_CHLT3;  Q3KMV0, DXR_CHLTA;  
B0BB58, DXR_CHLTB;  Q8KG43, DXR_CHLTE;  O84074, DXR_CHLTR;  
Q7NVY8, DXR_CHRVO;  Q97I58, DXR_CLOAB;  A7FW01, DXR_CLOB1;  
C3L0C4, DXR_CLOB6;  A6LSP7, DXR_CLOB8;  B2V4G1, DXR_CLOBA;  
B2TJ47, DXR_CLOBB;  A5I4K2, DXR_CLOBH;  C1FS67, DXR_CLOBJ;  
B1II57, DXR_CLOBK;  A7GG14, DXR_CLOBL;  B1KWL5, DXR_CLOBM;  
B8I6D9, DXR_CLOCE;  B9E1J4, DXR_CLOK1;  A5N834, DXR_CLOK5;  
A0Q0R4, DXR_CLONN;  Q0TPQ9, DXR_CLOP1;  Q8XJR1, DXR_CLOPE;  
A9KMX2, DXR_CLOPH;  Q0SSC6, DXR_CLOPS;  Q895K5, DXR_CLOTE;  
A3DE52, DXR_CLOTH;  Q485G4, DXR_COLP3;  Q6NGL1, DXR_CORDI;  
Q8FP80, DXR_COREF;  A4QF22, DXR_CORGB;  Q8NP10, DXR_CORGL;  
Q4JV26, DXR_CORJK;  Q0KA22, DXR_CUPNH;  Q470E3, DXR_CUPPJ;  
B3R2B1, DXR_CUPTR;  B1WNP5, DXR_CYAA5;  B8HVK1, DXR_CYAP4;  
B7KAT5, DXR_CYAP7;  B7K5G6, DXR_CYAP8;  Q47F86, DXR_DECAR;  
Q9RU84, DXR_DEIRA;  Q313H2, DXR_DESAG;  B1I2I8, DXR_DESAP;  
B8FR31, DXR_DESHD;  Q24UG4, DXR_DESHY;  A8ZTM6, DXR_DESOH;  
Q6AP35, DXR_DESPS;  A4J5Y5, DXR_DESRM;  Q72DR3, DXR_DESVH;  
A1VFB6, DXR_DESVV;  Q8X8Y1, DXR_ECO57;  P45568, DXR_ECOLI;  
C5BHC1, DXR_EDWI9;  Q3YRZ5, DXR_EHRCJ;  Q2GGR4, DXR_EHRCR;  
Q5FHA4, DXR_EHRRG;  Q5HB55, DXR_EHRRW;  B2KCJ9, DXR_ELUMP;  
B2VE12, DXR_ERWT9;  C4Z5K1, DXR_EUBE2;  C4ZA70, DXR_EUBR3;  
B1YI70, DXR_EXIS2;  C4L656, DXR_EXISA;  A7HLL7, DXR_FERNB;  
Q14G49, DXR_FRAT1;  A7NAP0, DXR_FRATF;  Q2A4P9, DXR_FRATH;  
B2SFW7, DXR_FRATM;  A0Q7Y5, DXR_FRATN;  Q0BN25, DXR_FRATO;  
Q5NEP6, DXR_FRATT;  A4IWJ1, DXR_FRATW;  Q8R622, DXR_FUSNN;  
B5EHV5, DXR_GEOBB;  B9M5C0, DXR_GEODF;  Q5L0J6, DXR_GEOKA;  
B3E7B0, DXR_GEOLS;  Q39W82, DXR_GEOMG;  Q74BW4, DXR_GEOSL;  
C6E518, DXR_GEOSM;  C5D9C1, DXR_GEOSW;  A5G7W2, DXR_GEOUR;  
Q7NID1, DXR_GLOVI;  Q5FPZ1, DXR_GLUOX;  Q7VM27, DXR_HAEDU;  
Q4QM93, DXR_HAEI8;  A5UDR7, DXR_HAEIE;  A5UHV9, DXR_HAEIG;  
P44055, DXR_HAEIN;  B8F4X2, DXR_HAEPS;  Q2SBQ3, DXR_HAHCH;  
B8CW61, DXR_HALOH;  Q7VIT0, DXR_HELHP;  B0THN7, DXR_HELMI;  
B6JKE8, DXR_HELP2;  B5Z9Y5, DXR_HELPG;  Q1CUT8, DXR_HELPH;  
Q9ZML6, DXR_HELPJ;  B2US45, DXR_HELPS;  P56139, DXR_HELPY;  
A4G4S7, DXR_HERAR;  Q5QUF4, DXR_IDILO;  A6SZP5, DXR_JANMA;  
Q28PJ0, DXR_JANSC;  Q9AJD7, DXR_KITGR;  C1D9F0, DXR_LARHH;  
Q1MRD4, DXR_LAWIP;  Q6AEY1, DXR_LEIXX;  B0SDN1, DXR_LEPBA;  
Q04U66, DXR_LEPBJ;  Q053M9, DXR_LEPBL;  B0SM60, DXR_LEPBP;  
Q72U08, DXR_LEPIC;  Q8F146, DXR_LEPIN;  Q92C37, DXR_LISIN;  
C1L2M3, DXR_LISMC;  Q720A5, DXR_LISMF;  B8DG10, DXR_LISMH;  
Q8Y7G4, DXR_LISMO;  A0AIB8, DXR_LISW6;  B1HQZ7, DXR_LYSSC;  
B9EBE2, DXR_MACCJ;  Q65R75, DXR_MANSM;  Q9XES0, DXR_MENPI;  
Q60BA4, DXR_METCA;  Q1H145, DXR_METFK;  B0JWW6, DXR_MICAN;  
Q2RJN4, DXR_MOOTA;  A0QJ14, DXR_MYCA1;  P64013, DXR_MYCBO;  
A1KML5, DXR_MYCBP;  C1AFY6, DXR_MYCBT;  Q7NC17, DXR_MYCGA;  
B8ZRU7, DXR_MYCLB;  Q9CBU3, DXR_MYCLE;  B2HJP9, DXR_MYCMM;  
Q73VS1, DXR_MYCPA;  Q8EWQ6, DXR_MYCPE;  A0QVH7, DXR_MYCS2;  
A5U6M4, DXR_MYCTA;  P9WNS0, DXR_MYCTO;  P9WNS1, DXR_MYCTU;  
A0PQ95, DXR_MYCUA;  B9L7Q2, DXR_NAUPA;  Q5F5X0, DXR_NEIG1;  
Q9JX33, DXR_NEIMA;  Q9K1G8, DXR_NEIMB;  Q0AEI0, DXR_NITEC;  
Q82U01, DXR_NITEU;  Q1QMN1, DXR_NITHX;  Q2YBA1, DXR_NITMU;  
Q3JCW9, DXR_NITOC;  Q3SRH8, DXR_NITWN;  Q5YS72, DXR_NOCFA;  
B2ITX3, DXR_NOSP7;  Q8YP49, DXR_NOSS1;  B6JH72, DXR_OLICO;  
Q8W250, DXR_ORYSJ;  A1B969, DXR_PARDP;  Q6MEL5, DXR_PARUW;  
P57985, DXR_PASMU;  Q6D8D9, DXR_PECAS;  C6DAI7, DXR_PECCP;  
Q3B6R4, DXR_PELLD;  B4SAR7, DXR_PELPB;  A1AQN8, DXR_PELPD;  
A5D2U3, DXR_PELTS;  Q4FM64, DXR_PELUB;  Q185R8, DXR_PEPD6;  
C0QTC4, DXR_PERMH;  Q7N8P3, DXR_PHOLL;  Q6LN30, DXR_PHOPR;  
Q8IKG4, DXR_PLAF7;  O96693, DXR_PLAFX;  B2RJX5, DXR_PORG3;  
Q7MUW3, DXR_PORGI;  B4S387, DXR_PROA2;  Q6A7K8, DXR_PROAC;  
A2C3T8, DXR_PROM1;  A2BXK2, DXR_PROM5;  Q319Z8, DXR_PROM9;  
Q7VB62, DXR_PROMA;  B4F2C9, DXR_PROMH;  Q7V6J8, DXR_PROMM;  
Q7V0W0, DXR_PROMP;  Q46JT6, DXR_PROMT;  A4SCF3, DXR_PROVI;  
Q48F65, DXR_PSE14;  A6V1D8, DXR_PSEA7;  B7V7G3, DXR_PSEA8;  
Q02RC2, DXR_PSEAB;  Q9KGU6, DXR_PSEAE;  Q4KHH0, DXR_PSEF5;  
C3K601, DXR_PSEFS;  A4XWT5, DXR_PSEMY;  A5W844, DXR_PSEP1;  
Q3KHA6, DXR_PSEPF;  B0KSA5, DXR_PSEPG;  Q88MH4, DXR_PSEPK;  
B1JBQ4, DXR_PSEPW;  Q886N7, DXR_PSESM;  Q4ZWS2, DXR_PSEU2;  
A4VJS7, DXR_PSEU5;  Q4FRH9, DXR_PSYA2;  Q1QA16, DXR_PSYCK;  
A1SYV7, DXR_PSYIN;  A5WGE7, DXR_PSYWF;  Q1LNF2, DXR_RALME;  
B2UB12, DXR_RALPJ;  Q8XZI5, DXR_RALSO;  B3PQ37, DXR_RHIE6;  
Q2K3K0, DXR_RHIEC;  Q1MB26, DXR_RHIL3;  Q92LP6, DXR_RHIME;  
C3M9M8, DXR_RHISN;  Q7URM5, DXR_RHOBA;  B6ISU5, DXR_RHOCS;  
Q2IW86, DXR_RHOP2;  Q07NI7, DXR_RHOP5;  Q6N5Q6, DXR_RHOPA;  
Q215E3, DXR_RHOPB;  Q136B0, DXR_RHOPS;  B3Q7J8, DXR_RHOPT;  
A3PJG0, DXR_RHOS1;  Q3J2X1, DXR_RHOS4;  A4WUH5, DXR_RHOS5;  
B9KRU3, DXR_RHOSK;  Q0S275, DXR_RHOSR;  Q5LSU9, DXR_RUEPO;  
Q1GGS3, DXR_RUEST;  A1AV71, DXR_RUTMC;  Q21HH8, DXR_SACD2;  
Q57T35, DXR_SALCH;  Q5PD59, DXR_SALPA;  Q8Z9A6, DXR_SALTI;  
Q8ZRP3, DXR_SALTY;  A8GIE2, DXR_SERP5;  A1S4P6, DXR_SHEAM;  
B8E7R0, DXR_SHEB2;  A3D2L1, DXR_SHEB5;  A9KUL1, DXR_SHEB9;  
Q085D6, DXR_SHEFN;  B0TP77, DXR_SHEHH;  A3QG97, DXR_SHELP;  
Q8EGG9, DXR_SHEON;  A8H6L0, DXR_SHEPA;  B8CQ79, DXR_SHEPW;  
A0KZ17, DXR_SHESA;  A8FY36, DXR_SHESH;  Q0HGW1, DXR_SHESM;  
Q0HT68, DXR_SHESR;  B1KNT7, DXR_SHEWM;  Q83MD3, DXR_SHIFL;  
A6UDH9, DXR_SINMW;  Q2NRL1, DXR_SODGM;  Q01QM3, DXR_SOLUE;  
Q82K41, DXR_STRAW;  Q9KYS1, DXR_STRCO;  B2V847, DXR_SULSY;  
Q67PA9, DXR_SYMTH;  Q31N26, DXR_SYNE7;  Q2JXQ9, DXR_SYNJA;  
Q2JM39, DXR_SYNJB;  Q9RCT1, DXR_SYNP6;  Q7U8C3, DXR_SYNPX;  
Q0IBN9, DXR_SYNS3;  Q3AZ20, DXR_SYNS9;  Q3AI71, DXR_SYNSC;  
Q55663, DXR_SYNY3;  Q8DK30, DXR_THEEB;  A8F4Z0, DXR_THELT;  
Q9WZZ1, DXR_THEMA;  B9KA80, DXR_THENN;  A5IIP4, DXR_THEP1;  
B0K9Q9, DXR_THEP3;  B0K1E5, DXR_THEPX;  B9L006, DXR_THERP;  
Q72KE2, DXR_THET2;  Q5SJZ6, DXR_THET8;  B5YI09, DXR_THEYD;  
C4L858, DXR_TOLAT;  Q73K78, DXR_TREDE;  O83610, DXR_TREPA;  
Q83IC8, DXR_TROW8;  Q83GY8, DXR_TROWT;  B1H060, DXR_UNCTG;  
A5CY29, DXR_VESOH;  A5F615, DXR_VIBC3;  A7MXZ4, DXR_VIBCB;  
Q9KPV8, DXR_VIBCH;  C3LQ26, DXR_VIBCM;  Q5E3E5, DXR_VIBF1;  
B5F9X0, DXR_VIBFM;  Q87ME3, DXR_VIBPA;  Q8DBF5, DXR_VIBVU;  
Q7MIG6, DXR_VIBVY;  Q8D2G6, DXR_WIGBR;  Q73GG3, DXR_WOLPM;  
B3CN89, DXR_WOLPP;  Q7M9M7, DXR_WOLSU;  Q5GTA4, DXR_WOLTR;  
C0R414, DXR_WOLWR;  Q8PML1, DXR_XANAC;  Q3BVL0, DXR_XANC5;  
Q4USQ4, DXR_XANC8;  B0RW72, DXR_XANCB;  Q8PAV9, DXR_XANCP;  
Q2P4B2, DXR_XANOM;  B2SR05, DXR_XANOP;  Q5H1E7, DXR_XANOR;  
B2I7P4, DXR_XYLF2;  Q9PEI0, DXR_XYLFA;  B0U242, DXR_XYLFM;  
Q87EH9, DXR_XYLFT;  A1JP78, DXR_YERE8;  A7FFH3, DXR_YERP3;  
Q1CAN0, DXR_YERPA;  B2JZ30, DXR_YERPB;  Q8ZH62, DXR_YERPE;  
A9R392, DXR_YERPG;  Q1CFF1, DXR_YERPN;  A4TL87, DXR_YERPP;  
Q667J3, DXR_YERPS;  B1JQG4, DXR_YERPY;  Q9X5F2, DXR_ZYMMO;  

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