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ENZYME entry: EC 1.1.1.27

Accepted Name
L-lactate dehydrogenase.
Alternative Name(s)
L-lactic acid dehydrogenase.
L-lactic dehydrogenase.
Reaction catalysed
(S)-lactate + NAD(+) <=> pyruvate + NADH
Comment(s)
  • Also oxidizes other (S)-2-hydroxymonocarboxylic acids.
  • NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.
Cross-references
PROSITEPDOC00062
BRENDA1.1.1.27
EC2PDB1.1.1.27
ExplorEnz1.1.1.27
PRIAM enzyme-specific profiles1.1.1.27
KEGG Ligand Database for Enzyme Nomenclature1.1.1.27
IUBMB Enzyme Nomenclature1.1.1.27
IntEnz1.1.1.27
MEDLINEFind literature relating to 1.1.1.27
MetaCyc1.1.1.27
UniProtKB/Swiss-Prot
Q81RW4, LDH1_BACAN;  P62047, LDH1_BACC1;  Q81EP4, LDH1_BACCR;  
Q63CN1, LDH1_BACCZ;  Q6HK31, LDH1_BACHK;  E8MJ15, LDH1_BIFL2;  
P59050, LDH1_BIFLO;  Q97MD1, LDH1_CLOAB;  Q839C1, LDH1_ENTFA;  
Q5FMB0, LDH1_LACAC;  P62052, LDH1_LACJO;  Q01462, LDH1_LACLA;  
P04034, LDH1_LACLC;  P56512, LDH1_LACPL;  Q92F65, LDH1_LISIN;  
Q724K3, LDH1_LISMF;  P33380, LDH1_LISMO;  A7WXP7, LDH1_STAA1;  
A6TY25, LDH1_STAA2;  Q2FK29, LDH1_STAA3;  Q2G218, LDH1_STAA8;  
A5IPA9, LDH1_STAA9;  Q2YV38, LDH1_STAAB;  Q5HJD7, LDH1_STAAC;  
A6QDL6, LDH1_STAAE;  P65255, LDH1_STAAM;  P65256, LDH1_STAAN;  
Q6GK73, LDH1_STAAR;  Q6GCN4, LDH1_STAAS;  A8Z0K3, LDH1_STAAT;  
P65257, LDH1_STAAW;  Q81K80, LDH2_BACAN;  P62048, LDH2_BACC1;  
Q816G3, LDH2_BACCR;  Q632G8, LDH2_BACCZ;  Q6HC14, LDH2_BACHK;  
E8ME30, LDH2_BIFL2;  P0CW93, LDH2_BIFLO;  Q97DC6, LDH2_CLOAB;  
Q838C9, LDH2_ENTFA;  Q5FKK7, LDH2_LACAC;  P62053, LDH2_LACJO;  
Q9CII4, LDH2_LACLA;  P0C2T6, LDH2_LACLC;  P0CI34, LDH2_LACLM;  
D8KFT1, LDH2_LACLN;  P59390, LDH2_LACPL;  Q92BI0, LDH2_LISIN;  
Q71ZD6, LDH2_LISMF;  Q8Y6Z6, LDH2_LISMO;  A7X6Y1, LDH2_STAA1;  
A6U4Y2, LDH2_STAA2;  Q2FDQ7, LDH2_STAA3;  Q2G1Y5, LDH2_STAA8;  
A5IW27, LDH2_STAA9;  Q2YWF6, LDH2_STAAB;  Q5HCV0, LDH2_STAAC;  
A6QK89, LDH2_STAAE;  P65258, LDH2_STAAM;  P99119, LDH2_STAAN;  
Q6GDK1, LDH2_STAAR;  Q6G674, LDH2_STAAS;  P0C7U6, LDH2_STAAT;  
Q8NUM9, LDH2_STAAW;  Q81XJ7, LDH3_BACAN;  P62049, LDH3_BACC1;  
Q815X8, LDH3_BACCR;  Q631X2, LDH3_BACCZ;  Q6HBQ8, LDH3_BACHK;  
Q9CGG8, LDH3_LACLA;  Q6ZMR3, LDH6A_HUMAN;  Q3T056, LDH6B_BOVIN;  
Q9BYZ2, LDH6B_HUMAN;  Q4R816, LDH6B_MACFA;  Q9PW06, LDHA_ALLMI;  
Q9W7M6, LDHA_AMBME;  A0A1F3, LDHA_BOSMU;  P19858, LDHA_BOVIN;  
Q98SL2, LDHA_CAICA;  P69080, LDHA_CHAAC;  O93541, LDHA_CHAGU;  
P00340, LDHA_CHICK;  P69081, LDHA_CHIRA;  Q9PW07, LDHA_COLLI;  
Q9W7K5, LDHA_CYPCA;  Q9PVK5, LDHA_DANRE;  Q9PW61, LDHA_DISEL;  
O93544, LDHA_DISMA;  O93542, LDHA_ELEMC;  Q92055, LDHA_FUNHE;  
P69083, LDHA_GILMI;  P69084, LDHA_GILSE;  O93540, LDHA_GOBGI;  
O93537, LDHA_HARAN;  P22988, LDHA_HORVU;  P00338, LDHA_HUMAN;  
O93545, LDHA_LEPNU;  Q9PW58, LDHA_LYCDA;  Q9BE24, LDHA_MACFA;  
Q9XT87, LDHA_MONDO;  P06151, LDHA_MOUSE;  P69085, LDHA_NOTAN;  
O93539, LDHA_NOTNE;  P69086, LDHA_PAGBO;  Q5R1W9, LDHA_PANTR;  
O93538, LDHA_PARCR;  O93543, LDHA_PARMG;  O93546, LDHA_PATTE;  
Q98SL0, LDHA_PELSJ;  P00339, LDHA_PIG;  Q5R5F0, LDHA_PONAB;  
P69082, LDHA_PSEBE;  Q9W7L3, LDHA_PYTRG;  P13491, LDHA_RABIT;  
P04642, LDHA_RAT;  O93401, LDHA_RHINC;  Q9P4B6, LDHA_RHIOR;  
Q9W7L5, LDHA_SCEUN;  P79912, LDHA_SCEWO;  O13276, LDHA_SPHAG;  
O13277, LDHA_SPHID;  O13278, LDHA_SPHLU;  P00341, LDHA_SQUAC;  
Q9PT43, LDHA_TRASE;  P42120, LDHA_XENLA;  Q9PVK4, LDHBA_DANRE;  
Q6DGK2, LDHBB_DANRE;  Q9PW05, LDHB_ALLMI;  P13743, LDHB_ANAPL;  
Q9YGL2, LDHB_ANGRO;  Q5E9B1, LDHB_BOVIN;  Q98SL1, LDHB_CAICA;  
P00337, LDHB_CHICK;  Q9PW04, LDHB_COLLI;  P20373, LDHB_FUNHE;  
P42122, LDHB_FUNPA;  P22989, LDHB_HORVU;  P07195, LDHB_HUMAN;  
Q4R5B6, LDHB_MACFA;  Q9XT86, LDHB_MONDO;  P16125, LDHB_MOUSE;  
A5A6N7, LDHB_PANTR;  Q98SK9, LDHB_PELSJ;  P00336, LDHB_PIG;  
Q1EG91, LDHB_POLSE;  P13490, LDHB_RABIT;  P42123, LDHB_RAT;  
Q9P4B5, LDHB_RHIOR;  Q9W7L4, LDHB_SCEUN;  P79913, LDHB_SCEWO;  
Q9YI05, LDHB_SQUAC;  Q9PT42, LDHB_TRASE;  P42119, LDHB_XENLA;  
Q06176, LDHC_FUNHE;  P07864, LDHC_HUMAN;  P00342, LDHC_MOUSE;  
Q9TSX5, LDHC_PIG;  P19629, LDHC_RAT;  Q29563, LDHC_VULVU;  
P42121, LDHC_XENLA;  P14561, LDHP_BACPS;  P20619, LDHX_BACPS;  
B9JTR0, LDH_AGRVS;  P10655, LDH_BACCA;  Q59244, LDH_BACCL;  
Q9K5Z8, LDH_BACHD;  Q65NP0, LDH_BACLD;  P00345, LDH_BACME;  
A8F9Q8, LDH_BACP2;  Q5WE04, LDH_BACSK;  P13714, LDH_BACSU;  
A7Z152, LDH_BACVZ;  B8DSV5, LDH_BIFA0;  Q0SP77, LDH_BORAP;  
Q662S5, LDH_BORBP;  O51114, LDH_BORBU;  B7J121, LDH_BORBZ;  
B2S1S1, LDH_BORHD;  A1QYN6, LDH_BORT9;  P93052, LDH_BOTBR;  
Q27888, LDH_CAEEL;  B3QX21, LDH_CHLT3;  A7FU32, LDH_CLOB1;  
C3KVF0, LDH_CLOB6;  A5I1Z6, LDH_CLOBH;  C1FMZ1, LDH_CLOBJ;  
B1IKX1, LDH_CLOBK;  A7GDK3, LDH_CLOBL;  B1L1N3, LDH_CLOBM;  
Q0TUX8, LDH_CLOP1;  Q8XP62, LDH_CLOPE;  Q0SWR1, LDH_CLOPS;  
Q892U0, LDH_CLOTE;  Q8KQC4, LDH_CLOTH;  P62050, LDH_CORDI;  
Q8FLV6, LDH_COREF;  A4QHW5, LDH_CORGB;  Q8NLN0, LDH_CORGL;  
Q4JY42, LDH_CORJK;  Q07251, LDH_CUPNH;  P50933, LDH_DEIRA;  
A4J898, LDH_DESRM;  P62051, LDH_DESVH;  A1VG02, LDH_DESVV;  
Q95028, LDH_DROME;  A7HM89, LDH_FERNB;  Q8RED8, LDH_FUSNN;  
B9LZ61, LDH_GEODF;  Q5L2S0, LDH_GEOKA;  P00344, LDH_GEOSE;  
C5D5V2, LDH_GEOSW;  A4IKL5, LDH_GEOTN;  Q7NG49, LDH_GLOVI;  
C5CGP2, LDH_KOSOT;  P00343, LDH_LACCA;  Q04CN9, LDH_LACDB;  
B2GBW0, LDH_LACF3;  O32765, LDH_LACHE;  P56511, LDH_LACPE;  
Q8GMJ0, LDH_LACRE;  Q1WSG2, LDH_LACS1;  P50934, LDH_LACSK;  
Q38V71, LDH_LACSS;  B9E9F9, LDH_MACCJ;  P29038, LDH_MAIZE;  
Q6F0L9, LDH_MESFL;  Q2RHG3, LDH_MOOTA;  Q2SS50, LDH_MYCCT;  
O52354, LDH_MYCGA;  P47698, LDH_MYCGE;  P0C0J2, LDH_MYCH2;  
Q4A8M8, LDH_MYCH7;  P0C0J3, LDH_MYCHJ;  P0C0J4, LDH_MYCHY;  
Q6KIP9, LDH_MYCMO;  P62054, LDH_MYCMS;  Q8EUG3, LDH_MYCPE;  
P78007, LDH_MYCPN;  Q98PG4, LDH_MYCPU;  Q8ELF0, LDH_OCEIH;  
Q59645, LDH_PEDAC;  Q03DZ7, LDH_PEDPA;  P33571, LDH_PETMA;  
A9BGZ9, LDH_PETMO;  Q7SI97, LDH_PLABA;  P84793, LDH_PLABE;  
P13774, LDH_PLAFA;  Q27743, LDH_PLAFD;  Q6A9C3, LDH_PROAC;  
A8F6M1, LDH_PSELT;  Q2S4R2, LDH_SALRD;  Q9P7P7, LDH_SCHPO;  
Q9EVR0, LDH_SELRU;  B9DN51, LDH_STACT;  Q5HL31, LDH_STAEQ;  
Q8CMZ0, LDH_STAES;  Q4L941, LDH_STAHJ;  Q49YJ3, LDH_STAS1;  
Q3K1C8, LDH_STRA1;  Q8E5N4, LDH_STRA3;  Q8DZY3, LDH_STRA5;  
C0M7H8, LDH_STRE4;  Q59828, LDH_STREI;  B4U309, LDH_STREM;  
A8AXK9, LDH_STRGC;  P26283, LDH_STRMU;  P65259, LDH_STRP1;  
Q04K99, LDH_STRP2;  P0DC18, LDH_STRP3;  B5E4V6, LDH_STRP4;  
Q5XC59, LDH_STRP6;  C1C7I6, LDH_STRP7;  P65261, LDH_STRP8;  
Q1JBQ9, LDH_STRPB;  Q1JLP1, LDH_STRPC;  Q1JGU2, LDH_STRPD;  
Q1J6L1, LDH_STRPF;  A2REG9, LDH_STRPG;  B1IC17, LDH_STRPI;  
B8ZQ84, LDH_STRPJ;  Q48TK0, LDH_STRPM;  P0A3M9, LDH_STRPN;  
P0DC19, LDH_STRPQ;  B5XLJ8, LDH_STRPZ;  P0A3N0, LDH_STRR6;  
A4W1K6, LDH_STRS2;  C0MFB5, LDH_STRS7;  A3CN70, LDH_STRSV;  
A4VVA3, LDH_STRSY;  Q5LZ83, LDH_STRT1;  Q5M3T6, LDH_STRT2;  
Q03K30, LDH_STRTD;  Q60009, LDH_STRTR;  B9DS53, LDH_STRU0;  
C1CEH8, LDH_STRZJ;  C1CKW1, LDH_STRZP;  C1CR83, LDH_STRZT;  
Q2JRH2, LDH_SYNJA;  Q2JJQ1, LDH_SYNJB;  P13715, LDH_THEAQ;  
P06150, LDH_THECA;  P16115, LDH_THEMA;  A5IL75, LDH_THEP1;  
B0KDA4, LDH_THEP3;  B0K226, LDH_THEPX;  B1LAF5, LDH_THESQ;  
Q7X5C9, LDH_THESW;  P62055, LDH_THET2;  Q5SJA1, LDH_THET8;  
Q27797, LDH_TOXGO;  P62056, LDH_TREDE;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-