ID   1.1.1.274
DE   2,5-didehydrogluconate reductase.
AN   2,5-diketo-D-gluconate reductase.
CA   2-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + NADPH.
CC   -!- Key enzyme in the microbial production of ascorbate.
CC   -!- Can also reduce ethyl 2-methylacetoacetate stereoselectively to ethyl
CC       (2R)-methyl-(3S)-hydroxybutanoate and can also accept some other
CC       beta-keto esters.
CC   -!- The identification of a bacterial beta-keto ester reductase as a 2,5-
CC       didehydrogluconate reductase links two previously separate areas of
CC       biocatalysis, i.e., asymmetric carbonyl reduction and microbial
CC       vitamin C production.
PR   PROSITE; PDOC00061;
DR   P06632, DKGA_CORSC ;  Q8XBT6, DKGA_ECO57 ;  Q46857, DKGA_ECOLI ;
DR   P58744, DKGA_SALTI ;  Q8ZM06, DKGA_SALTY ;  Q8ZI40, DKGA_YERPE ;
DR   P15339, DKGB_CORSS ;  Q8X7Z7, DKGB_ECO57 ;  P30863, DKGB_ECOLI ;
DR   Q8Z988, DKGB_SALTI ;  Q8ZRM7, DKGB_SALTY ;  Q8ZH36, DKGB_YERPE ;
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