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ENZYME entry: EC 1.1.1.284

Accepted Name
S-(hydroxymethyl)glutathione dehydrogenase.
Alternative Name(s)
ADH3.
Chi-ADH.
Class III alcohol dehydrogenase.
FDH.
Formaldehyde dehydrogenase.
Formaldehyde dehydrogenase (glutathione).
Formic dehydrogenase.
GD-FALDH.
Glutathione-dependent formaldehyde dehydrogenase.
GS-FDH.
NAD- and glutathione-dependent formaldehyde dehydrogenase.
NAD-dependent formaldehyde dehydrogenase.
NAD-linked formaldehyde dehydrogenase.
Reaction catalysed
S-(hydroxymethyl)glutathione + NAD(P)(+) <=> S-formylglutathione + NAD(P)H
Comment(s)
  • The substrate, S-(hydroxymethyl)glutathione, forms spontaneously from glutathione and formaldehyde; its rate of formation is increased in some bacteria by the presence of EC 4.4.1.22.
  • Forms part of the pathway that detoxifies formaldehyde, since the product is hydrolyzed by EC 3.1.2.12.
  • Also specifically reduces S-nitrosylglutathione.
  • Formerly EC 1.2.1.1.
Cross-references
PROSITEPDOC00058
BRENDA1.1.1.284
EC2PDB1.1.1.284
ExplorEnz1.1.1.284
PRIAM enzyme-specific profiles1.1.1.284
KEGG Ligand Database for Enzyme Nomenclature1.1.1.284
IUBMB Enzyme Nomenclature1.1.1.284
IntEnz1.1.1.284
MEDLINEFind literature relating to 1.1.1.284
MetaCyc1.1.1.284
UniProtKB/Swiss-Prot
P81600, ADHH_GADMO;  P72324, ADHI_RHOS4;  P81601, ADHL_GADMO;  
Q96533, ADHX_ARATH;  Q3ZC42, ADHX_BOVIN;  Q17335, ADHX_CAEEL;  
Q54TC2, ADHX_DICDI;  P46415, ADHX_DROME;  P19854, ADHX_HORSE;  
P11766, ADHX_HUMAN;  P93629, ADHX_MAIZE;  P28474, ADHX_MOUSE;  
P80360, ADHX_MYXGL;  P81431, ADHX_OCTVU;  A2XAZ3, ADHX_ORYSI;  
Q0DWH1, ADHX_ORYSJ;  P80572, ADHX_PEA;  O19053, ADHX_RABIT;  
P12711, ADHX_RAT;  P80467, ADHX_SAAHA;  P86884, ADHX_SCYCA;  
P79896, ADHX_SPAAU;  P78870, FADH1_SCHPO;  O74540, FADH2_SCHPO;  
P0CL53, FADH_ASPOR;  Q06099, FADH_CANMA;  P47734, FADH_METMR;  
P45382, FADH_PARDE;  O74685, FADH_PICPA;  P32771, FADH_YEAST;  
A7ZIA4, FRMA_ECO24;  Q8X5J4, FRMA_ECO57;  A7ZX04, FRMA_ECOHS;  
A1A835, FRMA_ECOK1;  Q0TKS7, FRMA_ECOL5;  Q8FKG1, FRMA_ECOL6;  
B1J085, FRMA_ECOLC;  P25437, FRMA_ECOLI;  B1LIP1, FRMA_ECOSM;  
Q1RFI7, FRMA_ECOUT;  P44557, FRMA_HAEIN;  P39450, FRMA_PHODP;  
Q3Z550, FRMA_SHISS;  P73138, FRMA_SYNY3;  

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