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ENZYME entry: EC 1.1.1.290

Accepted Name
4-phosphoerythronate dehydrogenase.
Alternative Name(s)
4-O-phosphoerythronate dehydrogenase.
4PE dehydrogenase.
Erythronate-4-phosphate dehydrogenase.
Reaction catalysed
4-phospho-D-erythronate + NAD(+) <=> (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + NADH
Cofactor(s)
NAD(+).
Comment(s)
  • This enzyme catalyzes a step in a bacterial pathway for the biosynthesis of pyridoxal 5'-phosphate.
  • The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD(+).
  • In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyzes the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)- hydroxy acid.
  • Cf. EC 1.1.1.399.
Cross-references
PROSITEPDOC00063
BRENDA1.1.1.290
EC2PDB1.1.1.290
ExplorEnz1.1.1.290
PRIAM enzyme-specific profiles1.1.1.290
KEGG Ligand Database for Enzyme Nomenclature1.1.1.290
IUBMB Enzyme Nomenclature1.1.1.290
IntEnz1.1.1.290
MEDLINEFind literature relating to 1.1.1.290
MetaCyc1.1.1.290
UniProtKB/Swiss-Prot
Q6F943, PDXB_ACIAD;  B7GY62, PDXB_ACIB3;  B7I5Z2, PDXB_ACIB5;  
B2HX89, PDXB_ACIBC;  B0VT23, PDXB_ACIBS;  A3M810, PDXB_ACIBT;  
B0VDM7, PDXB_ACIBY;  A0KLP0, PDXB_AERHH;  A4SNU1, PDXB_AERS4;  
Q0VQC3, PDXB_ALCBS;  B6EIW3, PDXB_ALISL;  C1DM66, PDXB_AZOVD;  
Q5LIR8, PDXB_BACFN;  Q64ZV5, PDXB_BACFR;  Q8A2E4, PDXB_BACTN;  
Q1LTA7, PDXB_BAUCH;  Q7VRU9, PDXB_BLOFL;  Q492H2, PDXB_BLOPB;  
B3PK14, PDXB_CELJU;  Q1QXV7, PDXB_CHRSD;  A8ADQ9, PDXB_CITK8;  
Q47XK1, PDXB_COLP3;  A9KEY5, PDXB_COXBN;  A9NAQ7, PDXB_COXBR;  
Q83AR8, PDXB_COXBU;  A7MH63, PDXB_CROS8;  A7ZPD6, PDXB_ECO24;  
B7UFX8, PDXB_ECO27;  B7MG84, PDXB_ECO45;  B7LBH4, PDXB_ECO55;  
Q8XCR0, PDXB_ECO57;  B5YXW1, PDXB_ECO5E;  B7NP01, PDXB_ECO7I;  
B7MXZ7, PDXB_ECO81;  B7M6K1, PDXB_ECO8A;  C4ZVL3, PDXB_ECOBW;  
B1X931, PDXB_ECODH;  A8A2I9, PDXB_ECOHS;  A1ADG9, PDXB_ECOK1;  
Q0TFC6, PDXB_ECOL5;  Q8FFH2, PDXB_ECOL6;  B1IXM2, PDXB_ECOLC;  
P05459, PDXB_ECOLI;  B7N5T2, PDXB_ECOLU;  B6I4U8, PDXB_ECOSE;  
B1LLS6, PDXB_ECOSM;  Q1R992, PDXB_ECOUT;  C5B8N0, PDXB_EDWI9;  
A4WCV4, PDXB_ENT38;  B7LLF0, PDXB_ESCF3;  Q2SJQ9, PDXB_HAHCH;  
Q31IH6, PDXB_HYDCU;  Q5QUE2, PDXB_IDILO;  B5XNR7, PDXB_KLEP3;  
Q5X6I6, PDXB_LEGPA;  Q5ZX15, PDXB_LEGPH;  Q5WXZ0, PDXB_LEGPL;  
A1U1I8, PDXB_MARHV;  A6VXM3, PDXB_MARMS;  Q6D2N5, PDXB_PECAS;  
C6DA76, PDXB_PECCP;  Q7N2B2, PDXB_PHOLL;  Q6LNU2, PDXB_PHOPR;  
Q7MV70, PDXB_PORGI;  B4EZF9, PDXB_PROMH;  Q48KQ3, PDXB_PSE14;  
Q15QG8, PDXB_PSEA6;  A6V8H9, PDXB_PSEA7;  B7UVK4, PDXB_PSEA8;  
Q02JM2, PDXB_PSEAB;  Q9I3W9, PDXB_PSEAE;  Q1I7B3, PDXB_PSEE4;  
Q4KFD1, PDXB_PSEF5;  C3K5G7, PDXB_PSEFS;  Q3IF36, PDXB_PSEHT;  
A4XTK4, PDXB_PSEMY;  A5W6I8, PDXB_PSEP1;  Q3K9D1, PDXB_PSEPF;  
B0KGD9, PDXB_PSEPG;  Q88L20, PDXB_PSEPK;  B1J5D7, PDXB_PSEPW;  
Q884R9, PDXB_PSESM;  Q4ZVE7, PDXB_PSEU2;  A4VKJ1, PDXB_PSEU5;  
Q4FV16, PDXB_PSYA2;  Q1QE21, PDXB_PSYCK;  A1SW94, PDXB_PSYIN;  
A5WHK7, PDXB_PSYWF;  A1AWW7, PDXB_RUTMC;  Q21LK8, PDXB_SACD2;  
B5EZQ4, PDXB_SALA4;  A9MJ55, PDXB_SALAR;  Q57LY4, PDXB_SALCH;  
B5FPL4, PDXB_SALDC;  B5R3Q1, PDXB_SALEP;  B5RCJ5, PDXB_SALG2;  
B4TBN9, PDXB_SALHS;  B4SZP2, PDXB_SALNS;  Q5PCV8, PDXB_SALPA;  
A9N474, PDXB_SALPB;  C0PZZ3, PDXB_SALPC;  B5BCH6, PDXB_SALPK;  
Q2S0U3, PDXB_SALRD;  B4TQA6, PDXB_SALSV;  P60801, PDXB_SALTI;  
P60802, PDXB_SALTY;  A8GH44, PDXB_SERP5;  A1S7K2, PDXB_SHEAM;  
B8EEB4, PDXB_SHEB2;  A3D669, PDXB_SHEB5;  A6WQ07, PDXB_SHEB8;  
A9KTV0, PDXB_SHEB9;  Q12P58, PDXB_SHEDO;  Q084S1, PDXB_SHEFN;  
B0TKZ7, PDXB_SHEHH;  A3QFC7, PDXB_SHELP;  Q8ECR2, PDXB_SHEON;  
A4Y882, PDXB_SHEPC;  A0KV91, PDXB_SHESA;  A8FTT7, PDXB_SHESH;  
Q0HKB6, PDXB_SHESM;  Q56731, PDXB_SHESP;  Q0HWL8, PDXB_SHESR;  
A1RIA7, PDXB_SHESW;  Q56733, PDXB_SHEVD;  B1KKP1, PDXB_SHEWM;  
B2TWA2, PDXB_SHIB3;  Q31YD8, PDXB_SHIBS;  Q32DL6, PDXB_SHIDS;  
Q0T2G5, PDXB_SHIF8;  Q83QR1, PDXB_SHIFL;  Q3YZP1, PDXB_SHISS;  
Q2NSH9, PDXB_SODGM;  C5BR49, PDXB_TERTT;  C4LF16, PDXB_TOLAT;  
A5CWD1, PDXB_VESOH;  Q9KQ92, PDXB_VIBCH;  Q5E452, PDXB_VIBF1;  
B5FFP0, PDXB_VIBFM;  Q87MN8, PDXB_VIBPA;  B7VL81, PDXB_VIBTL;  
Q8DB36, PDXB_VIBVU;  Q7MIT6, PDXB_VIBVY;  Q8D2P6, PDXB_WIGBR;  
A1JL55, PDXB_YERE8;  A7FGL9, PDXB_YERP3;  Q1C676, PDXB_YERPA;  
B2K8H7, PDXB_YERPB;  Q8D0U3, PDXB_YERPE;  A9R7V0, PDXB_YERPG;  
Q1CHL8, PDXB_YERPN;  A4TM66, PDXB_YERPP;  Q668W7, PDXB_YERPS;  
B1JGI0, PDXB_YERPY;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
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