ID 1.1.1.3 DE homoserine dehydrogenase. CA (1) L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH. CA (2) L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH. CC -!- The enzyme from Saccharomyces cerevisiae acts most rapidly with CC NAD(+); the Neurospora enzyme with NADP(+). CC -!- The enzyme from Escherichia coli is a multifunctional protein, which CC also catalyzes the reaction of EC 2.7.2.4. DR P00561, AK1H_ECOLI ; P27725, AK1H_SERMA ; P00562, AK2H_ECOLI ; DR Q9SA18, AKH1_ARATH ; P49079, AKH1_MAIZE ; O81852, AKH2_ARATH ; DR P49080, AKH2_MAIZE ; P57290, AKH_BUCAI ; Q8K9U9, AKH_BUCAP ; DR Q89AR4, AKH_BUCBP ; P37142, AKH_DAUCA ; P44505, AKH_HAEIN ; DR P19582, DHOM_BACSU ; P08499, DHOM_CORGL ; Q5B998, DHOM_EMENI ; DR Q9ZL20, DHOM_HELPJ ; P56429, DHOM_HELPY ; Q9CGD8, DHOM_LACLA ; DR P52985, DHOM_LACLC ; P37143, DHOM_METGL ; Q58997, DHOM_METJA ; DR P63630, DHOM_MYCBO ; P46806, DHOM_MYCLE ; P9WPX0, DHOM_MYCTO ; DR P9WPX1, DHOM_MYCTU ; Q5F8J4, DHOM_NEIG1 ; P29365, DHOM_PSEAE ; DR O94671, DHOM_SCHPO ; P52986, DHOM_SYNY3 ; P31116, DHOM_YEAST ; DR P37144, DHON_METGL ; //