ID   1.1.1.300
DE   NADP-retinol dehydrogenase.
AN   all-trans retinal reductase.
AN   all-trans-retinol dehydrogenase.
AN   NADP(H)-dependent retinol dehydrogenase/reductase.
AN   retinol dehydrogenase [NADP(+)].
CA   all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.
CC   -!- Greater catalytic efficiency in the reductive direction.
CC   -!- This observation, and the enzyme's localization at the entrance to
CC       the mitochondrial matrix, suggest that it may function to protect
CC       mitochondria against oxidative stress associated with the highly
CC       reactive retinal produced from dietary beta-carotene by
CC       EC 1.13.11.63.
CC   -!- Km-values for NADP(+) and NADPH are at least 800-fold lower than
CC       those for NAD(+) and NADH.
CC   -!- This enzyme differs from EC 1.1.1.105 which prefers NAD(+) and NADH.
CC   -!- Formerly EC 1.1.1.n2.
DR   O60218, AK1BA_HUMAN;  C9JRZ8, AK1BF_HUMAN;  P16116, ALDR_BOVIN ;
DR   P15121, ALDR_HUMAN ;  P45376, ALDR_MOUSE ;  P80276, ALDR_PIG   ;
DR   P15122, ALDR_RABIT ;  P07943, ALDR_RAT   ;  O77769, DHRS3_BOVIN;
DR   O75911, DHRS3_HUMAN;  O88876, DHRS3_MOUSE;  Q8SPU8, DHRS4_BOVIN;
DR   Q99LB2, DHRS4_MOUSE;  Q8WNV7, DHRS4_PIG  ;  Q9GKX2, DHRS4_RABIT;
DR   Q8VID1, DHRS4_RAT  ;  A1L1W4, RD10A_DANRE;  Q6DCT3, RD10A_XENLA;
DR   Q7T2D1, RD10B_DANRE;  Q6NRV4, RD10B_XENLA;  Q8HZT6, RDH10_BOVIN;
DR   Q8IZV5, RDH10_HUMAN;  Q8VCH7, RDH10_MOUSE;  Q80ZF7, RDH10_RAT  ;
DR   Q5XGF7, RDH10_XENTR;  Q8TC12, RDH11_HUMAN;  Q9QYF1, RDH11_MOUSE;
DR   P59837, RDH12_BOVIN;  Q96NR8, RDH12_HUMAN;  Q8BYK4, RDH12_MOUSE;
DR   Q8NBN7, RDH13_HUMAN;  Q8CEE7, RDH13_MOUSE;  Q17QW3, RDH14_BOVIN;
DR   Q9HBH5, RDH14_HUMAN;  Q9ERI6, RDH14_MOUSE;  Q9N126, RDH8_BOVIN ;
DR   Q9NYR8, RDH8_HUMAN ;
//