To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC

Accepted Name
2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase.
Alternative Name(s)
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase.
Reaction catalysed
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) <=> 2-oxo-2H-pyran-4,6-dicarboxylate + NADPH
  • The enzyme does not act on unsubstituted aliphatic or aromatic aldehydes or glucose; NAD(+) can replace NADP(+), but with lower affinity.
  • The enzyme was initially believed to act on 4-carboxy-2-hydroxy- cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy- cis,cis-muconate.
  • However, later studies showed that the substrate is the hemiacetal form, and the product is 2-oxo-2H-pyran-4,6-dicarboxylate.
  • Formerly EC
PRIAM enzyme-specific profiles1.1.1.312
KEGG Ligand Database for Enzyme Nomenclature1.1.1.312
IUBMB Enzyme Nomenclature1.1.1.312
MEDLINEFind literature relating to

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-