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ENZYME entry: EC 1.1.1.335

Accepted Name
UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase.
Reaction catalysed
UDP-N-acetyl-2-amino-2-deoxy-alpha-D-glucuronate + NAD(+) <=> UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + NADH
Comment(s)
  • This enzyme participates in the biosynthetic pathway for UDP-alpha-D- ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide.
  • The enzymes from Pseudomonas aeruginosa serotype O5 and Thermus thermophilus form a complex with the the enzyme catalyzing the next step the pathway (EC 2.6.1.98).
  • The enzyme also possesses an EC 1.1.99.2 activity, and utilizes the 2-oxoglutarate produced by EC 2.6.1.98 to regenerate the tightly bound NAD(+).
  • The enzymes from Bordetella pertussis and Chromobacterium violaceum do not bind NAD(+) as tightly and do not require 2-oxoglutarate to function.
Cross-references
BRENDA1.1.1.335
EC2PDB1.1.1.335
ExplorEnz1.1.1.335
PRIAM enzyme-specific profiles1.1.1.335
KEGG Ligand Database for Enzyme Nomenclature1.1.1.335
IUBMB Enzyme Nomenclature1.1.1.335
IntEnz1.1.1.335
MEDLINEFind literature relating to 1.1.1.335
MetaCyc1.1.1.335
UniProtKB/Swiss-Prot
G3XD23, WBPB_PSEAE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
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