ID 1.1.1.34 DE hydroxymethylglutaryl-CoA reductase (NADPH). AN 3-hydroxy-3-methylglutaryl-coenzyme A reductase. AN HMG-CoA reductase. CA (R)-mevalonate + CoA + 2 NADP(+) = (3S)-hydroxy-3-methylglutaryl-CoA + CA 2 H(+) + 2 NADPH. CC -!- The enzyme is inactivated by EC 2.7.11.31 and reactivated by CC EC 3.1.3.47. DR P14891, HMDH1_ARATH; Q4WHZ1, HMDH1_ASPFU; P34135, HMDH1_DICDI; DR I1RXX1, HMDH1_GIBZE; O64966, HMDH1_GOSHI; P29057, HMDH1_HEVBR; DR A2X8W3, HMDH1_ORYSI; Q0DY59, HMDH1_ORYSJ; P48020, HMDH1_SOLTU; DR P12683, HMDH1_YEAST; P43256, HMDH2_ARATH; Q4WSY2, HMDH2_ASPFU; DR Q9XEL8, HMDH2_CAPAN; P34136, HMDH2_DICDI; O64967, HMDH2_GOSHI; DR P29058, HMDH2_HEVBR; P48022, HMDH2_SOLLC; Q41437, HMDH2_SOLTU; DR P12684, HMDH2_YEAST; Q00583, HMDH3_HEVBR; Q9XHL5, HMDH3_ORYSJ; DR Q41438, HMDH3_SOLTU; Q9YAS4, HMDH_AERPE ; O76819, HMDH_AGRIP ; DR O28538, HMDH_ARCFU ; Q9Y7D2, HMDH_ASPTE ; Q0C8L9, HMDH_ASPTN ; DR P54960, HMDH_BLAGE ; A7Z064, HMDH_BOVIN ; P48021, HMDH_CAMAC ; DR A0A1D8PD39, HMDH_CANAL ; Q03163, HMDH_CATRO ; P00347, HMDH_CRIGR ; DR O74164, HMDH_CYBJA ; P14773, HMDH_DROME ; B2KX91, HMDH_GANLU ; DR S0DQM8, HMDH_GIBF5 ; P0CT44, HMDH_GIBFU ; B0R6J9, HMDH_HALS3 ; DR Q59468, HMDH_HALVD ; P04035, HMDH_HUMAN ; O24594, HMDH_MAIZE ; DR P09610, HMDH_MESAU ; Q58116, HMDH_METJA ; O26662, HMDH_METTH ; DR Q01237, HMDH_MOUSE ; Q01559, HMDH_NICSY ; Q12649, HMDH_PHYB8 ; DR Q1W675, HMDH_PIG ; Q5R6N3, HMDH_PONAB ; Q9V1R3, HMDH_PYRAB ; DR O59469, HMDH_PYRHO ; Q29512, HMDH_RABIT ; P51639, HMDH_RAT ; DR O08424, HMDH_SACS2 ; P16237, HMDH_SCHMA ; Q10283, HMDH_SCHPO ; DR P16393, HMDH_STRPU ; P20715, HMDH_XENLA ; A0A0A1C3I2, HMGR1_PANGI; DR A0A0A1C930, HMR2A_PANGI; U5JCC6, HMR2B_PANGI; Q8J0F4, MLCD_PENCI ; DR Q3S2U3, MOKG_MONPI ; C8VN86, PBCC_EMENI ; //