ENZYME entry: EC 1.1.1.356

Accepted Name
GDP-L-colitose synthase.
Reaction catalysed
GDP-beta-L-colitose + NAD(P)(+) <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NAD(P)H
Comment(s)
  • The enzyme is involved in biosynthesis of L-colitose, a 3,6- dideoxyhexose found in the O-antigen of Gram-negative lipopolysaccharides, where it catalyzes the reaction in the reverse direction.
  • The enzyme also performs the NAD(P)H-dependent epimerisation at C-5 of the sugar.
  • The enzyme from Yersinia pseudotuberculosis is Si-specific with respect to NAD(P)H.
Cross-references
BRENDA1.1.1.356
EC2PDB1.1.1.356
ExplorEnz1.1.1.356
PRIAM enzyme-specific profiles1.1.1.356
KEGG Ligand Database for Enzyme Nomenclature1.1.1.356
IUBMB Enzyme Nomenclature1.1.1.356
IntEnz1.1.1.356
MEDLINEFind literature relating to 1.1.1.356
MetaCyc1.1.1.356
UniProtKB/Swiss-Prot
G4WJD3, COLC_YERPU

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