ENZYME entry: EC 1.1.1.375

Accepted Name
L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)).
Alternative Name(s)
Lactate/malate dehydrogenase.
Reaction catalysed
A (2S)-2-hydroxycarboxylate + NAD(P)(+) <=> a 2-oxocarboxylate + NAD(P)H
Comment(s)
  • The enzyme from the archaeon Methanocaldococcus jannaschii catalyzes the reversible oxidation of (2R)-3-sulfolactate and (S)-malate to 3-sulfopyruvate and oxaloacetate, respectively (note that (2R)-3- sulfolactate has the same stereochemical configuration as (2S)-2- hydroxycarboxylates).
  • The enzyme can use both NADH and NADPH, although activity is higher with NADPH.
  • The oxidation of (2R)-3-sulfolactate was observed only in the presence of NADP(+).
  • The same organism also possesses an NAD(+)-specific enzyme with similar activity, cf. EC 1.1.1.337.
Cross-references
BRENDA1.1.1.375
EC2PDB1.1.1.375
ExplorEnz1.1.1.375
PRIAM enzyme-specific profiles1.1.1.375
KEGG Ligand Database for Enzyme Nomenclature1.1.1.375
IUBMB Enzyme Nomenclature1.1.1.375
IntEnz1.1.1.375
MEDLINEFind literature relating to 1.1.1.375
MetaCyc1.1.1.375
UniProtKB/Swiss-Prot
Q60176, MDH_METJA

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