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ENZYME

ENZYME entry: EC 1.1.1.399

Accepted Name
2-oxoglutarate reductase
Reaction catalysed
(R)-2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH
Comment(s)
  • The enzyme catalyzes a reversible reaction.
  • The enzyme from the bacterium Peptoniphilus asaccharolyticus is specific for (R)-2-hydroxyglutarate.
  • The SerA enzyme from Escherichia coli can also accept (S)-2- hydroxyglutarate with a much higher Km, and also catalyzes the activity of EC 1.1.1.95.
Cross-references
BRENDA1.1.1.399
EC2PDB1.1.1.399
ExplorEnz1.1.1.399
PRIAM enzyme-specific profiles1.1.1.399
KEGG Ligand Database for Enzyme Nomenclature1.1.1.399
IUBMB Enzyme Nomenclature1.1.1.399
IntEnz1.1.1.399
MEDLINEFind literature relating to 1.1.1.399
MetaCyc1.1.1.399
Rhea expert-curated reactions1.1.1.399
UniProtKB/Swiss-Prot
D2RJU7, HGDH_ACIFVP40510, SER33_YEASTP35136, SERA_BACSU
Q5EAD2, SERA_BOVINQ54UH8, SERA_DICDIP0A9T2, SERA_ECO57
P0A9T1, SERA_ECOL6P0A9T0, SERA_ECOLIP43885, SERA_HAEIN
O43175, SERA_HUMANQ60HD7, SERA_MACFAP0A545, SERA_MYCBO
O33116, SERA_MYCLEP9WNX2, SERA_MYCTOP9WNX3, SERA_MYCTU
A5A6P1, SERA_PANTRA5GFY8, SERA_PIGQ5R7M2, SERA_PONAB
P87228, SERA_SCHPOP0A9T3, SERA_SHIFLP73821, SERA_SYNY3
P40054, SERA_YEAST

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