ID   1.1.1.423
DE   (1R,2S)-ephedrine 1-dehydrogenase.
AN   ephedrine dehydrogenase.
CA   (1R,2S)-ephedrine + NAD(+) = (S)-2-methylamino-1-phenylpropan-1-one +
CA   H(+) + NADH.
CC   -!- The enzyme, characterized from the bacterium Arthrobacter sp. TS-15,
CC       acts on a broad range of different aryl-alkyl ketones, such as
CC       haloketones, ketoamines, diketones, and ketoesters.
CC   -!- It exhibits a strict enantioselectivity and accepts various types of
CC       aryl groups including phenyl-, pyridyl-, thienyl-, and furyl-rings,
CC       but the presence of an aromatic ring is essential for the activity.
CC   -!- In addition, the presence of a functional group on the alkyl chain,
CC       such as an amine, a halogen, or a ketone, is also crucial.
CC   -!- When acting on diketones, it catalyzes the reduction of only the keto
CC       group closest to the ring, with no further reduction to the diol. cf.
CC       EC 1.1.1.422 and EC 1.5.1.18.
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