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ENZYME

ENZYME entry: EC 1.1.1.436

Accepted Name
lactate dehydrogenase (NAD(+),ferredoxin)
Alternative Name(s)
electron bifurcating LDH/Etf complex
Reaction catalysed
lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate
Comment(s)
  • The enzyme, isolated from the bacterium Acetobacterium woodii, uses flavin-based electron confurcation to drive endergonic lactate oxidation with NAD(+) as oxidant at the expense of simultaneous exergonic electron flow from reduced ferredoxin to NAD(+).
  • Formerly EC 1.3.1.110.
Cross-references
BRENDA1.1.1.436
EC2PDB1.1.1.436
ExplorEnz1.1.1.436
PRIAM enzyme-specific profiles1.1.1.436
KEGG Ligand Database for Enzyme Nomenclature1.1.1.436
IUBMB Enzyme Nomenclature1.1.1.436
IntEnz1.1.1.436
MEDLINEFind literature relating to 1.1.1.436
MetaCyc1.1.1.436
Rhea expert-curated reactions1.1.1.436
UniProtKB/Swiss-Prot
H6LBB0, LCTB_ACEWDH6LBB1, LCTC_ACEWDH6LBS1, LCTD_ACEWD

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