ENZYME entry: EC 1.1.1.44

Accepted Name
Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).
Alternative Name(s)
6-phosphogluconic carboxylase.
6-phosphogluconic dehydrogenase.
6PGD.
Phosphogluconic acid dehydrogenase.
Reaction catalysed
6-phospho-D-gluconate + NADP(+) <=> D-ribulose 5-phosphate + CO(2) + NADPH
Comment(s)
  • The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions.
  • Highly specific for NADP(+).
  • Cf. EC 1.1.1.343.
Cross-references
PROSITEPDOC00390
BRENDA1.1.1.44
EC2PDB1.1.1.44
ExplorEnz1.1.1.44
PRIAM enzyme-specific profiles1.1.1.44
KEGG Ligand Database for Enzyme Nomenclature1.1.1.44
IUBMB Enzyme Nomenclature1.1.1.44
IntEnz1.1.1.44
MEDLINEFind literature relating to 1.1.1.44
MetaCyc1.1.1.44
UniProtKB/Swiss-Prot
Q9FWA3, 6GPD3_ARATH;  Q9SH69, 6PGD1_ARATH;  Q9LI00, 6PGD1_ORYSJ;  
Q94KU1, 6PGD1_SPIOL;  P38720, 6PGD1_YEAST;  Q9FFR3, 6PGD2_ARATH;  
Q2R480, 6PGD2_ORYSJ;  Q94KU2, 6PGD2_SPIOL;  P53319, 6PGD2_YEAST;  
P37754, 6PGD9_ECOLX;  P70718, 6PGD_AGGAC;  P52207, 6PGD_BACLI;  
P80859, 6PGD_BACSU;  P57208, 6PGD_BUCAI;  Q9ZHD9, 6PGD_BUCAP;  
Q89AX5, 6PGD_BUCBP;  Q17761, 6PGD_CAEEL;  O13287, 6PGD_CANAX;  
P41570, 6PGD_CERCA;  Q9PKX7, 6PGD_CHLMU;  Q9Z8I3, 6PGD_CHLPN;  
O84066, 6PGD_CHLTR;  P41581, 6PGD_CITAM;  P41582, 6PGD_CITDI;  
P41583, 6PGD_CITFR;  O60037, 6PGD_CUNEL;  Q8TA03, 6PGD_DICDI;  
P41572, 6PGD_DROME;  P41573, 6PGD_DROSI;  P00350, 6PGD_ECOLI;  
C8VP36, 6PGD_EMENI;  P41574, 6PGD_ESCVU;  Q7VMX4, 6PGD_HAEDU;  
P43774, 6PGD_HAEIN;  P52209, 6PGD_HUMAN;  P41576, 6PGD_KLEPN;  
Q9CHU6, 6PGD_LACLA;  P96789, 6PGD_LACLM;  Q9DCD0, 6PGD_MOUSE;  
P14332, 6PGD_PIG;  P41575, 6PGD_RAOPL;  P41577, 6PGD_RAOTE;  
P85968, 6PGD_RAT;  P14062, 6PGD_SALTY;  P78812, 6PGD_SCHPO;  
P00349, 6PGD_SHEEP;  P41578, 6PGD_SHIBO;  P41579, 6PGD_SHIDY;  
P37756, 6PGD_SHIFL;  P41580, 6PGD_SHISO;  Q5HFR2, 6PGD_STAAC;  
Q931R3, 6PGD_STAAM;  P63334, 6PGD_STAAN;  Q6GGI7, 6PGD_STAAR;  
Q6G954, 6PGD_STAAS;  P63335, 6PGD_STAAW;  Q5HP42, 6PGD_STAEQ;  
Q8CP47, 6PGD_STAES;  P21577, 6PGD_SYNE7;  P52208, 6PGD_SYNY3;  
O83351, 6PGD_TREPA;  P31072, 6PGD_TRYBB;  

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