ID 1.1.1.62 DE 17beta-estradiol 17-dehydrogenase. AN 17beta-estradiol dehydrogenase. AN 17beta-HSD. AN 17beta-hydroxysteroid dehydrogenase. AN 20alpha-hydroxysteroid dehydrogenase. AN estrogen 17-oxidoreductase. CA (1) 17beta-estradiol + NAD(+) = estrone + H(+) + NADH. CA (2) 17beta-estradiol + NADP(+) = estrone + H(+) + NADPH. CC -!- The enzyme oxidizes or reduces the hydroxy/keto group on C17 of CC estrogens and androgens in mammals and regulates the biological CC potency of these steroids. CC -!- The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.270. CC -!- The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related CC compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, it is CC Si-specific with respect to NAD(P)(+). DR Q04828, AK1C1_HUMAN; Q95JH7, AK1C1_MACFA; Q95JH6, AK1C1_MACFU; DR Q5REQ0, AK1C1_PONAB; P52895, AK1C2_HUMAN; P42330, AK1C3_HUMAN; DR Q5R7C9, AK1C3_PONAB; P17516, AK1C4_HUMAN; Q95JH5, AK1C4_MACFA; DR Q95JH4, AK1C4_MACFU; Q6P3L6, DH12A_DANRE; Q5XG41, DH12A_XENLA; DR Q6QA33, DH12B_DANRE; Q8AVY8, DH12B_XENLA; Q8NBQ5, DHB11_HUMAN; DR Q4JK73, DHB11_MACFA; Q9EQ06, DHB11_MOUSE; Q5NVG2, DHB11_PONAB; DR Q6AYS8, DHB11_RAT ; O57314, DHB12_ANAPL; Q5E9H7, DHB12_BOVIN; DR Q53GQ0, DHB12_HUMAN; Q4R5G7, DHB12_MACFA; O70503, DHB12_MOUSE; DR Q6P7R8, DHB12_RAT ; Q28IU1, DHB12_XENTR; Q7Z5P4, DHB13_HUMAN; DR Q8VCR2, DHB13_MOUSE; Q5M875, DHB13_RAT ; Q9MYP6, DHB14_BOVIN; DR Q9BPX1, DHB14_HUMAN; P14061, DHB1_HUMAN ; P51656, DHB1_MOUSE ; DR Q1WNP0, DHB1_PANTR ; P51657, DHB1_RAT ; P37059, DHB2_HUMAN ; DR P51658, DHB2_MOUSE ; Q62730, DHB2_RAT ; P37058, DHB3_HUMAN ; DR P70385, DHB3_MOUSE ; O54939, DHB3_RAT ; P56937, DHB7_HUMAN ; DR O88736, DHB7_MOUSE ; Q62904, DHB7_RAT ; Q9GME3, DHB8_CALJA ; DR Q5TJF5, DHB8_CANLF ; Q92506, DHB8_HUMAN ; P50171, DHB8_MOUSE ; DR Q9XT00, DHB8_PIG ; Q6MGB5, DHB8_RAT ; Q3ZBV9, DHR11_BOVIN; DR Q71R50, DHR11_CHICK; Q6UWP2, DHR11_HUMAN; Q3U0B3, DHR11_MOUSE; DR Q3T001, H17B6_BOVIN; O14756, H17B6_HUMAN; Q9R092, H17B6_MOUSE; DR O54753, H17B6_RAT ; O02691, HCD2_BOVIN ; O18404, HCD2_DROME ; DR Q99714, HCD2_HUMAN ; O08756, HCD2_MOUSE ; O70351, HCD2_RAT ; DR Q93W57, HSDA_SESIN ; Q8LKV5, HSDB_SESIN ; A0A140FAN3, HSD_PINMS ; //