ENZYME entry: EC 1.1.3.6
| Accepted Name |
|---|
| Cholesterol oxidase.
|
| Alternative Name(s) |
|---|
| Cholesterol-O(2) oxidoreductase. |
| Reaction catalysed |
|---|
| Cholesterol + O(2) <=> cholest-5-en-3-one + H(2)O(2) |
| Cofactor(s) |
|---|
| FAD.
|
| Comment(s) |
|---|
- Cholesterol oxidases are secreted bacterial bifunctional enzymes that
catalyze the first two steps in the degradation of cholesterol.
- The enzyme catalyzes the oxidation of the 3-beta-hydroxyl group to a
keto group, and the isomerization of the double bond in the oxidized
steroid ring system from the Delta(5) position to the Delta(6)
position (cf. EC 5.3.3.1).
|
| Cross-references |
|---|
| PROSITE | PDOC00543 |
| BRENDA | 1.1.3.6 |
| EC2PDB | 1.1.3.6 |
| ExplorEnz | 1.1.3.6 |
| PRIAM enzyme-specific profiles | 1.1.3.6 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.3.6 |
| IUBMB Enzyme Nomenclature | 1.1.3.6 |
| IntEnz | 1.1.3.6 |
| MEDLINE | Find literature relating to 1.1.3.6 |
| MetaCyc | 1.1.3.6 |
| UniProtKB/Swiss-Prot |
|
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