ENZYME

ENZYME entry: EC 1.1.99.18

Accepted Name

Cellobiose dehydrogenase (acceptor).

Alternative Name(s)

CBOR.

CDH.

Cellobiose dehydrogenase.

Cellobiose dehydrogenase (quinone).

Cellobiose oxidase.

Cellobiose oxidoreductase.

Cellobiose-quinone oxidoreductase.

Reaction catalysed

Cellobiose + acceptor <=> cellobiono-1,5-lactone + reduced acceptor

Cofactor(s)

FAD; Heme.

Comment(s)

2,6-dichloroindophenol can act as acceptor.
Also acts, more slowly, on cello-oligosaccharides, lactose and D-glucosyl-1,4-beta-D-mannose.
Includes EC 1.1.5.1, which is now known to be a proteolytic product of this enzyme.
The enzyme from the white rot fungus Phanerochaete chrysosporium is unusual in having two redoxin domains, one containing a flavin and the other a protoheme group.
It transfers reducing equivalents from cellobiose to two types of redox acceptor: two-electron oxidants, including redox dyes, benzoquinones and molecular oxygen and one-electron oxidants, including semiquinone species, Fe(2+) complexes and the model acceptor cytochrome c.
Formerly EC 1.1.3.25.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature