ENZYME entry: EC 1.1.99.18

Accepted Name
Cellobiose dehydrogenase (acceptor).
Alternative Name(s)
CBOR.
CDH.
Cellobiose dehydrogenase.
Cellobiose dehydrogenase (quinone).
Cellobiose oxidase.
Cellobiose oxidoreductase.
Cellobiose-quinone oxidoreductase.
Reaction catalysed
Cellobiose + acceptor <=> cellobiono-1,5-lactone + reduced acceptor
Cofactor(s)
FAD; Heme.
Comment(s)
  • 2,6-dichloroindophenol can act as acceptor.
  • Also acts, more slowly, on cello-oligosaccharides, lactose and D-glucosyl-1,4-beta-D-mannose.
  • Includes EC 1.1.5.1, which is now known to be a proteolytic product of this enzyme.
  • The enzyme from the white rot fungus Phanerochaete chrysosporium is unusual in having two redoxin domains, one containing a flavin and the other a protoheme group.
  • It transfers reducing equivalents from cellobiose to two types of redox acceptor: two-electron oxidants, including redox dyes, benzoquinones and molecular oxygen and one-electron oxidants, including semiquinone species, Fe(2+) complexes and the model acceptor cytochrome c.
  • Formerly EC 1.1.3.25.
Cross-references
BRENDA1.1.99.18
EC2PDB1.1.99.18
ExplorEnz1.1.99.18
PRIAM enzyme-specific profiles1.1.99.18
KEGG Ligand Database for Enzyme Nomenclature1.1.99.18
IUBMB Enzyme Nomenclature1.1.99.18
IntEnz1.1.99.18
MEDLINEFind literature relating to 1.1.99.18
MetaCyc1.1.99.18
UniProtKB/Swiss-Prot
Q01738, CDH_PHACH

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