To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 1.1.99.31

Accepted Name
(S)-mandelate dehydrogenase.
Alternative Name(s)
L(+)-mandelate dehydrogenase.
MDH.
Reaction catalysed
(S)-2-hydroxy-2-phenylacetate + acceptor <=> 2-oxo-2-phenylacetate + reduced acceptor
Comment(s)
  • While all enzymes of this family oxidize the (S)-enantiomer of an alpha-hydroxy acid to an alpha-oxo acid, the ultimate oxidant (oxygen, intramolecular heme or some other acceptor) depends on the particular enzyme.
  • Transfers the electron pair from FMNH(2) to a component of the electron transport chain, most probably ubiquinone.
  • It is part of a metabolic pathway in Pseudomonads that allows these organisms to utilize mandelic acid, derivatized from the common soil metabolite amygdalin, as the sole source of carbon and energy.
  • Has a large active-site pocket and preferentially binds substrates with longer sidechains, e.g. 2-hydroxyoctanoate rather than 2-hydroxybutyrate.
  • It also prefers substrates that, like (S)-mandelate, have beta unsaturation, e.g. (indol-3-yl)glycolate compared with (indol-3- yl)lactate.
  • Esters of mandelate, such as methyl (S)-mandelate, are also substrates.
Cross-references
PROSITEPDOC00482
BRENDA1.1.99.31
EC2PDB1.1.99.31
ExplorEnz1.1.99.31
PRIAM enzyme-specific profiles1.1.99.31
KEGG Ligand Database for Enzyme Nomenclature1.1.99.31
IUBMB Enzyme Nomenclature1.1.99.31
IntEnz1.1.99.31
MEDLINEFind literature relating to 1.1.99.31
MetaCyc1.1.99.31
UniProtKB/Swiss-Prot
P32953, CYBL_RHOGR;  P20932, MDLB_PSEPU;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-