ENZYME entry: EC

Accepted Name
(S)-mandelate dehydrogenase.
Alternative Name(s)
L(+)-mandelate dehydrogenase.
Reaction catalysed
(S)-2-hydroxy-2-phenylacetate + acceptor <=> 2-oxo-2-phenylacetate + reduced acceptor
  • While all enzymes of this family oxidize the (S)-enantiomer of an alpha-hydroxy acid to an alpha-oxo acid, the ultimate oxidant (oxygen, intramolecular heme or some other acceptor) depends on the particular enzyme.
  • Transfers the electron pair from FMNH(2) to a component of the electron transport chain, most probably ubiquinone.
  • It is part of a metabolic pathway in Pseudomonads that allows these organisms to utilize mandelic acid, derivatized from the common soil metabolite amygdalin, as the sole source of carbon and energy.
  • Has a large active-site pocket and preferentially binds substrates with longer sidechains, e.g. 2-hydroxyoctanoate rather than 2-hydroxybutyrate.
  • It also prefers substrates that, like (S)-mandelate, have beta unsaturation, e.g. (indol-3-yl)glycolate compared with (indol-3- yl)lactate.
  • Esters of mandelate, such as methyl (S)-mandelate, are also substrates.
PRIAM enzyme-specific profiles1.1.99.31
KEGG Ligand Database for Enzyme Nomenclature1.1.99.31
IUBMB Enzyme Nomenclature1.1.99.31
MEDLINEFind literature relating to
P32953, CYBL_RHOGR;  P20932, MDLB_PSEPU;  

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