ENZYME entry: EC 1.10.2.2

Accepted Name
Quinol--cytochrome-c reductase.
Alternative Name(s)
Complex III (mitochondrial electron transport).
Cytochrome bc1 complex.
Ubiquinol--cytochrome-c reductase.
Ubiquinone--cytochrome-c oxidoreductase.
Reaction catalysed
Quinol + 2 ferricytochrome c <=> quinone + 2 ferrocytochrome c + 2 H(+)
Comment(s)
  • The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain.
  • It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria.
  • The mammalian enzyme contains cytochromes b-562, b-566 and C(1), and a 2-iron ferredoxin.
  • Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non- cytoplasmic compartment (cf. EC 1.6.99.3).
Cross-references
PROSITEPDOC00171
BRENDA1.10.2.2
EC2PDB1.10.2.2
ExplorEnz1.10.2.2
PRIAM enzyme-specific profiles1.10.2.2
KEGG Ligand Database for Enzyme Nomenclature1.10.2.2
IUBMB Enzyme Nomenclature1.10.2.2
IntEnz1.10.2.2
MEDLINEFind literature relating to 1.10.2.2
MetaCyc1.10.2.2
UniProtKB/Swiss-Prot
P29677, MPPA_SOLTU;  Q6NGA3, QCRB_CORDI;  Q8FNR2, QCRB_COREF;  
Q79VE9, QCRB_CORGL;  P63886, QCRB_MYCBO;  P15878, QCRB_MYCLE;  
P9WP36, QCRB_MYCTO;  P9WP37, QCRB_MYCTU;  Q9X806, QCRB_STRCO;  
Q9ZFB6, QCRB_STRLI;  Q6NGA1, QCRC_CORDI;  Q8FNR0, QCRC_COREF;  
Q8NNK5, QCRC_CORGL;  P63888, QCRC_MYCBO;  O69583, QCRC_MYCLE;  
P9WP34, QCRC_MYCTO;  P9WP35, QCRC_MYCTU;  P49729, UCRI1_TOBAC;  
P51132, UCRI2_TOBAC;  P51133, UCRI3_TOBAC;  P51134, UCRI4_TOBAC;  
P51135, UCRI5_TOBAC;  O31214, UCRI_ALLVD;  Q69BJ9, UCRI_AOTAZ;  
P81380, UCRI_BLAVI;  P13272, UCRI_BOVIN;  P51130, UCRI_BRADU;  
Q5ZLR5, UCRI_CHICK;  Q69BK1, UCRI_CHLAE;  Q69BK0, UCRI_COLPO;  
Q69BK4, UCRI_GORGO;  P47985, UCRI_HUMAN;  Q69BJ8, UCRI_LAGLA;  
P49727, UCRI_MAIZE;  Q9CR68, UCRI_MOUSE;  P07056, UCRI_NEUCR;  
Q69BK6, UCRI_PANPA;  Q69BK5, UCRI_PANTR;  P05417, UCRI_PARDE;  
Q69BK3, UCRI_PONPY;  P20788, UCRI_RAT;  P0CY48, UCRI_RHOCA;  
D5ANZ2, UCRI_RHOCB;  P23136, UCRI_RHORU;  Q02762, UCRI_RHOSH;  
Q1RIA5, UCRI_RICBR;  Q92IR2, UCRI_RICCN;  Q4UKR6, UCRI_RICFE;  
Q9ZDQ5, UCRI_RICPR;  Q68XA0, UCRI_RICTY;  Q69BJ7, UCRI_SAISC;  
Q09154, UCRI_SCHPO;  P37841, UCRI_SOLTU;  Q69BJ6, UCRI_SYMSY;  
Q69BK2, UCRI_THEGE;  P08067, UCRI_YEAST;  

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