ENZYME entry: EC 1.10.3.10

Accepted Name
Ubiquinol oxidase (H(+)-transporting).
Alternative Name(s)
Cytochrome bb3 oxidase.
Cytochrome bd-II oxidase.
Cytochrome bo oxidase.
Reaction catalysed
2 ubiquinol + O(2) + n H(+)(Side 1) <=> 2 ubiquinone + 2 H(2)O + n H(+)(Side 2)
Cofactor(s)
Cu cation; Heme.
Comment(s)
  • This terminal oxidase enzyme generates proton motive force by two mechanisms: (1) transmembrane charge separation resulting from utilizing protons and electrons originating from opposite sides of the membrane to generate water, and (2) active pumping of protons across the membrane.
  • The bioenergetic efficiency (the number of charges driven across the membrane per electron used to reduce oxygen to water) depends on the enzyme; for example, for the bo(3) oxidase it is 2, while for the bd-II oxidase it is 1.
  • Cf. EC 1.10.3.14.
Cross-references
BRENDA1.10.3.10
EC2PDB1.10.3.10
ExplorEnz1.10.3.10
PRIAM enzyme-specific profiles1.10.3.10
KEGG Ligand Database for Enzyme Nomenclature1.10.3.10
IUBMB Enzyme Nomenclature1.10.3.10
IntEnz1.10.3.10
MEDLINEFind literature relating to 1.10.3.10
MetaCyc1.10.3.10
UniProtKB/Swiss-Prot
P26458, APPB_ECOLI;  P26459, APPC_ECOLI;  P57543, CYOB_BUCAI;  
Q8K994, CYOB_BUCAP;  Q89AA4, CYOB_BUCBP;  P0ABJ0, CYOB_ECO57;  
P0ABI9, CYOB_ECOL6;  P0ABI8, CYOB_ECOLI;  Q9I426, CYOB_PSEAE;  
Q9WWR2, CYOB_PSEPU;  

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