ENZYME entry: EC 1.10.99.2

Accepted Name
Ribosyldihydronicotinamide dehydrogenase (quinone).
Alternative Name(s)
N-ribosyldihydronicotinamide dehydrogenase (quinone).
NAD(P)H:quinone oxidoreductase 2.
NQO(2).
NRH:quinone oxidoreductase 2.
QR2.
Quinone reductase 2.
Reaction catalysed
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone <=> 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone
Cofactor(s)
FAD; Zinc.
Comment(s)
  • Unlike EC 1.6.5.2, this quinone reductase cannot use NADH or NADPH; instead it uses N-ribosyl- and N-alkyldihydronicotinamides.
  • Polycyclic aromatic hydrocarbons, such as benz[a]anthracene, and the estrogens 17-beta-estradiol and diethylstilbestrol are potent inhibitors, but dicoumarol is only a very weak inhibitor.
  • This enzyme can catalyze both 2-electron and 4-electron reductions, but one-electron acceptors, such as potassium ferricyanide, cannot be reduced.
Cross-references
BRENDA1.10.99.2
EC2PDB1.10.99.2
ExplorEnz1.10.99.2
PRIAM enzyme-specific profiles1.10.99.2
KEGG Ligand Database for Enzyme Nomenclature1.10.99.2
IUBMB Enzyme Nomenclature1.10.99.2
IntEnz1.10.99.2
MEDLINEFind literature relating to 1.10.99.2
MetaCyc1.10.99.2
UniProtKB/Swiss-Prot
P16083, NQO2_HUMAN;  Q9JI75, NQO2_MOUSE;  Q5RBB9, NQO2_PONAB;  
Q6AY80, NQO2_RAT;  

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