ENZYME entry: EC 1.11.1.10

Accepted Name
Chloride peroxidase.
Alternative Name(s)
Chloroperoxidase.
CPO.
Vanadium haloperoxidase.
Reaction catalysed
RH + Cl(-) + H(2)O(2) <=> RCl + 2 H(2)O
Cofactor(s)
Heme.
Comment(s)
  • Brings about the chlorination of a range of organic molecules, forming stable C-Cl bonds.
  • Also oxidizes bromide and iodide.
  • Enzymes of this type are either heme-thiolate proteins, or contain vanadate.
  • A secreted enzyme produced by the ascomycetous fungus Caldariomyces fumago (Leptoxyphium fumago) is an example of the heme-thiolate type.
  • It catalyzes the production of hypochlorous acid by transferring one oxygen atom from H(2)O(2) to chloride.
  • At a separate site it catalyzes the chlorination of activated aliphatic and aromatic substrates, via HClO and derived chlorine species.
  • In the absence of halides, it shows peroxidase (e.g. phenol oxidation) and peroxygenase activities.
  • The latter inserts oxygen from H(2)O(2) into, for example, styrene (side chain epoxidation) and toluene (benzylic hydroxylation), however, these activities are less pronounced than its activity with halides.
  • Has little activity with non-activated substrates such as aromatic rings, ethers or saturated alkanes.
  • The chlorinating peroxidase produced by ascomycetous fungi (e.g. Curvularia inaequalis) is an example of a vanadium chloroperoxidase, and is related to bromide peroxidase (EC 1.11.1.18).
  • It contains vanadate and oxidizes chloride, bromide and iodide into hypohalous acids.
  • In the absence of halides, it peroxygenates organic sulfides and oxidizes ABTS (2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid)) but no phenols.
Cross-references
PROSITEPDOC51405
BRENDA1.11.1.10
EC2PDB1.11.1.10
ExplorEnz1.11.1.10
PRIAM enzyme-specific profiles1.11.1.10
KEGG Ligand Database for Enzyme Nomenclature1.11.1.10
IUBMB Enzyme Nomenclature1.11.1.10
IntEnz1.11.1.10
MEDLINEFind literature relating to 1.11.1.10
MetaCyc1.11.1.10
UniProtKB/Swiss-Prot
P04963, PRXC_CALFU;  P49053, PRXC_CURIN;  O31158, PRXC_PSEFL;  
P25026, PRXC_PSEPY;  O31168, PRXC_STRAU;  P49323, PRXC_STRLI;  
Q55921, PRXC_SYNY3;  

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