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ENZYME

ENZYME entry: EC 1.11.1.13

PURL: https://purl.expasy.org/enzyme/EC/1.11.1.13
Accepted Name
manganese peroxidase
Alternative Name(s)
Mn-dependent peroxidase
Reaction catalysed
2 Mn(2+) + H2O2 + 2 H(+) = 2 Mn(3+) + 2 H2O
Comment(s)
  • The enzyme from white rot basidiomycetes is involved in the oxidative degradation of lignin.
  • The enzyme oxidizes a bound Mn(2+) ion to Mn(3+) in the presence of hydrogen peroxide.
  • The product, Mn(3+), is released from the active site in the presence of a chelator (mostly oxalate and malate) that stabilizes it against disproportionation to Mn(2+) and insoluble Mn(4+).
  • The complexed Mn(3+) ion can diffuse into the lignified cell wall, where it oxidizes phenolic components of lignin and other organic substrates.
  • It is inactive with veratryl alcohol or nonphenolic substrates.
Cross-references
Rhea expert-curated reactions1.11.1.13
ExplorEnz1.11.1.13
IUBMB Enzyme Nomenclature1.11.1.13
UniProtKB/Swiss-Prot
Q02567, PEM1_PHACHQ70LM3, PEM2_PHLRAP78733, PEM3_PHACH
Q96TS6, PEM3_PHLRAP19136, PEM4_PHACHQ9URB1, PEM5_PHACH
P83918, PEM_IRPLA
BRENDA1.11.1.13
MetaCyc1.11.1.13
KEGG Ligand Database for Enzyme Nomenclature1.11.1.13
EC2PDB1.11.1.13
MEDLINEFind literature relating to 1.11.1.13

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.-.-
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