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ENZYME entry: EC 1.11.1.13

Accepted Name
Manganese peroxidase.
Alternative Name(s)
Mn-dependent peroxidase.
Reaction catalysed
2 Mn(2+) + 2 H(+) + H(2)O(2) <=> 2 Mn(3+) + 2 H(2)O
Cofactor(s)
Heme.
Comment(s)
  • The enzyme from white rot basidiomycetes is involved in the oxidative degradation of lignin.
  • The enzyme oxidizes a bound Mn(2+) ion to Mn(3+) in the presence of hydrogen peroxide.
  • The product, Mn(3+), is released from the active site in the presence of a chelator (mostly oxalate and malate) that stabilizes it against disproportionation to Mn(2+) and insoluble Mn(4+).
  • The complexed Mn(3+) ion can diffuse into the lignified cell wall, where it oxidizes phenolic components of lignin and other organic substrates.
  • It is inactive with veratryl alcohol or nonphenolic substrates.
Cross-references
PROSITEPDOC00394
BRENDA1.11.1.13
EC2PDB1.11.1.13
ExplorEnz1.11.1.13
PRIAM enzyme-specific profiles1.11.1.13
KEGG Ligand Database for Enzyme Nomenclature1.11.1.13
IUBMB Enzyme Nomenclature1.11.1.13
IntEnz1.11.1.13
MEDLINEFind literature relating to 1.11.1.13
MetaCyc1.11.1.13
UniProtKB/Swiss-Prot
Q02567, PEM1_PHACH;  Q70LM3, PEM2_PHLRA;  P78733, PEM3_PHACH;  
Q96TS6, PEM3_PHLRA;  P19136, PEM4_PHACH;  Q9URB1, PEM5_PHACH;  
P83918, PEM_IRPLA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.1.-
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