ENZYME entry: EC 1.11.1.14

Accepted Name
Lignin peroxidase.
Alternative Name(s)
Diarylpropane oxygenase.
Diarylpropane peroxidase.
Ligninase I.
LiP.
Reaction catalysed
(3,4-dimethoxyphenyl)methanol + H(2)O(2) <=> 3,4-dimethoxybenzaldehyde + 2 H(2)O
Cofactor(s)
Heme.
Comment(s)
  • Involved in the oxidative breakdown of lignin by white-rot basidiomycete fungi.
  • The enzyme from Phanerochaete chrysosporium oxidizes typical peroxidase dye substrates at the heme iron, a reaction involving the formation of Compound II (Fe(IV)=O); it also oxidizes (3,4- dimethoxyphenyl)methanol (veratryl alcohol) to the radical cation.
  • The bound veratryl alcohol radical is proposed to bring about the oxidative cleavage of C-C and ether (C-O-C) bonds in lignin model compounds of the diarylpropane and arylpropane-aryl ether type.
Cross-references
PROSITEPDOC00394
BRENDA1.11.1.14
EC2PDB1.11.1.14
ExplorEnz1.11.1.14
PRIAM enzyme-specific profiles1.11.1.14
KEGG Ligand Database for Enzyme Nomenclature1.11.1.14
IUBMB Enzyme Nomenclature1.11.1.14
IntEnz1.11.1.14
MEDLINEFind literature relating to 1.11.1.14
MetaCyc1.11.1.14
UniProtKB/Swiss-Prot
P49012, LIG2_PHACH;  P21764, LIG3_PHACH;  P11542, LIG4_PHACH;  
P11543, LIG5_PHACH;  P50622, LIG6_PHACH;  P06181, LIG8_PHACH;  
P31837, LIGA_PHACH;  P20011, LIGA_TRAVE;  P31838, LIGB_PHACH;  
P20012, LIGB_TRAVE;  P20013, LIGC_TRAVE;  P20010, LIG_PHLRA;  

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