ENZYME entry: EC 1.11.1.15

Accepted Name
Peroxiredoxin.
Alternative Name(s)
AhpC.
Alkyl hydroperoxide reductase C22.
PRDX.
Prx.
Thioredoxin peroxidase.
TrxPx.
Tryparedoxin peroxidase.
TXNPx.
Reaction catalysed
2 R'-SH + ROOH <=> R'-S-S-R' + H(2)O + ROH
Comment(s)
  • Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins.
  • They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins.
  • The peroxidase reaction comprises two steps centered around a redox- active cysteine called the peroxidatic cysteine.
  • All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid).
  • The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes.
  • For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants (R'-SH) (e.g. thioredoxin, AhpF, tryparedoxin or AhpD), completing the catalytic cycle.
  • In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond.
  • To recycle the disulfide, known atypical 2-Cys Prxs appear to use thioredoxin as an electron donor.
  • The 1-Cys Prxs conserve only the peroxidatic cysteine, so that its oxidized form is directly reduced to cysteine by the reductant molecule.
Cross-references
BRENDA1.11.1.15
EC2PDB1.11.1.15
ExplorEnz1.11.1.15
PRIAM enzyme-specific profiles1.11.1.15
KEGG Ligand Database for Enzyme Nomenclature1.11.1.15
IUBMB Enzyme Nomenclature1.11.1.15
IntEnz1.11.1.15
MEDLINEFind literature relating to 1.11.1.15
MetaCyc1.11.1.15
UniProtKB/Swiss-Prot
O17433, 1CPX_DIRIM;  P38013, AHP1_YEAST;  P82954, AHPC_ACICA;  
P80239, AHPC_BACSU;  P83117, AHPC_DELAC;  P0AE10, AHPC_ECO57;  
P0AE09, AHPC_ECOL6;  P0AE08, AHPC_ECOLI;  A0R1V9, AHPC_MYCS2;  
P9WQB6, AHPC_MYCTO;  P9WQB7, AHPC_MYCTU;  P72314, AHPC_RHORU;  
P0A252, AHPC_SALTI;  P0A251, AHPC_SALTY;  P0AE11, AHPC_SHIFL;  
Q2FJN4, AHPC_STAA3;  P0A0B7, AHPC_STAA8;  Q2YVK2, AHPC_STAAB;  
Q5HIR5, AHPC_STAAC;  P0A0B5, AHPC_STAAM;  P99074, AHPC_STAAN;  
Q6GJR7, AHPC_STAAR;  Q6GC91, AHPC_STAAS;  P0A0B6, AHPC_STAAW;  
Q5HRY1, AHPC_STAEQ;  Q8CMQ2, AHPC_STAES;  Q4L376, AHPC_STAHJ;  
Q49UT8, AHPC_STAS1;  C1F4K1, AHPD_ACIC5;  B8J9Z2, AHPD_ANAD2;  
Q2IMQ8, AHPD_ANADE;  A7HCA3, AHPD_ANADF;  B4UA87, AHPD_ANASK;  
A8HQP5, AHPD_AZOC5;  B2IHZ4, AHPD_BEII9;  Q9ANL0, AHPD_BRADU;  
A5ENR3, AHPD_BRASB;  A4YYT0, AHPD_BRASO;  B2SAW2, AHPD_BRUA1;  
Q2YKW2, AHPD_BRUA2;  Q578J2, AHPD_BRUAB;  A9MBZ4, AHPD_BRUC2;  
Q8YCF2, AHPD_BRUME;  A9WZ04, AHPD_BRUSI;  Q8FVW4, AHPD_BRUSU;  
B8GVX4, AHPD_CAUCN;  Q9A268, AHPD_CAUCR;  C3PGV9, AHPD_CORA7;  
Q6NGT4, AHPD_CORDI;  C4LJ26, AHPD_CORK4;  B6IZ19, AHPD_COXB2;  
A9KBI4, AHPD_COXBN;  A9N917, AHPD_COXBR;  Q83BM5, AHPD_COXBU;  
Q0RH96, AHPD_FRAAA;  A8L1J2, AHPD_FRASN;  A9H8D2, AHPD_GLUDA;  
Q0BUC5, AHPD_GRABC;  Q0BXT2, AHPD_HYPNA;  Q1IJ49, AHPD_KORVE;  
Q0AKM4, AHPD_MARMM;  B0UAJ8, AHPD_METS4;  B8EJZ2, AHPD_METSB;  
A0QGI9, AHPD_MYCA1;  B1MJX0, AHPD_MYCA9;  P0A5N5, AHPD_MYCBO;  
A1KLC4, AHPD_MYCBP;  C1AQZ5, AHPD_MYCBT;  B2HD59, AHPD_MYCMM;  
Q73ZL4, AHPD_MYCPA;  Q50441, AHPD_MYCS2;  A5U5C5, AHPD_MYCTA;  
P9WQB4, AHPD_MYCTO;  P9WQB5, AHPD_MYCTU;  A0PSD4, AHPD_MYCUA;  
Q5YT53, AHPD_NOCFA;  A6X5N3, AHPD_OCHA4;  B6IQZ3, AHPD_RHOCS;  
C0ZYQ9, AHPD_RHOE4;  Q07I00, AHPD_RHOP5;  Q20Y19, AHPD_RHOPB;  
Q02BZ5, AHPD_SOLUE;  A5VCB6, AHPD_SPHWW;  Q82IC5, AHPD_STRAW;  
Q7AKI6, AHPD_STRCO;  B1W2G7, AHPD_STRGG;  Q9X5V1, AHPD_STRVD;  
Q96291, BAS1A_ARATH;  Q9C5R8, BAS1B_ARATH;  Q96468, BAS1_HORVU;  
Q6ER94, BAS1_ORYSJ;  P84729, BAS1_PINST;  O24364, BAS1_SPIOL;  
P80602, BAS1_WHEAT;  P9WID8, BCPB_MYCTO;  P9WID9, BCPB_MYCTU;  
Q796Y8, BCP_BACSU;  Q9ZHF0, BCP_BUCAP;  Q83CY8, BCP_COXBU;  
P0AE54, BCP_ECO57;  P0AE53, BCP_ECOL6;  P0AE52, BCP_ECOLI;  
P44411, BCP_HAEIN;  Q9ZMU4, BCP_HELPJ;  P55979, BCP_HELPY;  
P9WIE0, BCP_MYCTO;  P9WIE1, BCP_MYCTU;  P0AE55, BCP_SHIFL;  
P19476, CR29_ENTHI;  P40553, DOT5_YEAST;  P40581, GPX3_YEAST;  
P56577, MALF2_MALFU;  P56578, MALF3_MALFU;  P0C0L2, OSMC_ECOLI;  
P0C0L3, OSMC_SHIFL;  Q9MB35, PERQ_SEDLI;  Q6UBI3, PERQ_SUASA;  
O43099, PMP20_ASPFU;  Q5ASN8, PMP20_EMENI;  Q01116, PMP20_LIPKO;  
O14313, PMP20_SCHPO;  P14292, PMPA_CANBO;  P14293, PMPB_CANBO;  
Q69TY4, PR2E1_ORYSJ;  Q7F8S5, PR2E2_ORYSJ;  Q5E947, PRDX1_BOVIN;  
P0CB50, PRDX1_CHICK;  Q9JKY1, PRDX1_CRIGR;  Q9V3P0, PRDX1_DROME;  
Q6DV14, PRDX1_GECJA;  Q06830, PRDX1_HUMAN;  P35700, PRDX1_MOUSE;  
Q6B4U9, PRDX1_MYOLU;  Q63716, PRDX1_RAT;  Q9BGI3, PRDX2_BOVIN;  
Q8K3U7, PRDX2_CRIGR;  P32119, PRDX2_HUMAN;  Q2PFZ3, PRDX2_MACFA;  
Q61171, PRDX2_MOUSE;  P52552, PRDX2_PIG;  Q5RC63, PRDX2_PONAB;  
P35704, PRDX2_RAT;  P35705, PRDX3_BOVIN;  P30048, PRDX3_HUMAN;  
P20108, PRDX3_MOUSE;  Q5REY3, PRDX3_PONAB;  Q9Z0V6, PRDX3_RAT;  
Q9BGI2, PRDX4_BOVIN;  P0CV91, PRDX4_CROAT;  Q555L5, PRDX4_DICDI;  
Q13162, PRDX4_HUMAN;  O08807, PRDX4_MOUSE;  Q9Z0V5, PRDX4_RAT;  
Q9BGI1, PRDX5_BOVIN;  Q9GLW7, PRDX5_CHLAE;  P30044, PRDX5_HUMAN;  
P86241, PRDX5_MESAU;  P99029, PRDX5_MOUSE;  Q9GLW9, PRDX5_PAPHA;  
Q9R063, PRDX5_RAT;  P83200, PRDX5_VULVU;  O77834, PRDX6_BOVIN;  
Q5ZJF4, PRDX6_CHICK;  P30041, PRDX6_HUMAN;  Q2PFL9, PRDX6_MACFA;  
P86215, PRDX6_MESAU;  O08709, PRDX6_MOUSE;  Q9TSX9, PRDX6_PIG;  
Q5R7E0, PRDX6_PONAB;  O35244, PRDX6_RAT;  Q9NL98, PRDX_ASCSU;  
P34227, PRX1_YEAST;  Q7G959, PRX2A_ARATH;  Q9XEX2, PRX2B_ARATH;  
Q9SRZ4, PRX2C_ARATH;  Q9FR35, PRX2C_ORYSJ;  O22711, PRX2D_ARATH;  
Q949U7, PRX2E_ARATH;  Q9M7T0, PRX2F_ARATH;  Q9SDD6, PRX2F_ORYSJ;  
P44758, PRX5_HAEIN;  Q9LU86, PRXQ_ARATH;  Q75SY5, PRXQ_GENTR;  
P0C5D4, PRXQ_ORYSI;  P0C5D5, PRXQ_ORYSJ;  Q6QPJ6, PRXQ_POPJC;  
Q5S1S6, PRXQ_WHEAT;  Q9L3Q5, PRXU_EUBAC;  O94561, PRX_SCHPO;  
P23161, R20K_CLOPA;  P0C5C8, REHYA_ORYSI;  P0C5C9, REHYA_ORYSJ;  
P0C5D0, REHYB_ORYSI;  P0C5D1, REHYB_ORYSJ;  O04005, REHY_ARATH;  
P52571, REHY_BROSE;  P52572, REHY_HORVU;  A2SZW8, REHY_MAIZE;  
Q6E2Z6, REHY_MEDTR;  P52574, REHY_TORRU;  Q6W8Q2, REHY_WHEAT;  
P48822, TDX1_BRUMA;  Q21824, TDX1_CAEEL;  Q17172, TDX2_BRUMA;  
Q8RCY5, TDXH1_CALS4;  Q6L240, TDXH1_PICTO;  Q55060, TDXH1_SULME;  
Q974S8, TDXH1_SULTO;  Q9HKX0, TDXH1_THEAC;  Q8R844, TDXH2_CALS4;  
Q6L140, TDXH2_PICTO;  O33665, TDXH2_SULME;  Q96XS5, TDXH2_SULTO;  
Q9HJL3, TDXH2_THEAC;  Q9Y9L0, TDXH_AERPE;  O67024, TDXH_AQUAE;  
O29969, TDXH_ARCFU;  Q8KBN8, TDXH_CHLTE;  A2BJD9, TDXH_HYPBU;  
A8A9P0, TDXH_IGNH4;  Q58146, TDXH_METJA;  A4FWZ9, TDXH_METM5;  
Q8PYP6, TDXH_METMA;  Q6LY19, TDXH_METMP;  O26262, TDXH_METTH;  
Q57109, TDXH_METTM;  A6UPH7, TDXH_METVS;  Q74NC6, TDXH_NANEQ;  
Q9UZV4, TDXH_PYRAB;  Q8U218, TDXH_PYRFU;  O58966, TDXH_PYRHO;  
A3DKL1, TDXH_STAMF;  P95895, TDXH_SULSO;  Q5JF30, TDXH_THEKO;  
Q9WZR4, TDXH_THEMA;  A5IIX7, TDXH_THEP1;  Q979N7, TDXH_THEVO;  
Q73RS4, TDXH_TREDE;  Q90384, TDX_CYNPY;  Q8T6C4, TDX_ECHGR;  
Q8SS85, TDX_ENCCU;  P91883, TDX_FASHE;  Q91191, TDX_ONCMY;  
Q26695, TDX_TRYBR;  Q9Y7F0, TSA1_CANAL;  O74887, TSA1_SCHPO;  
P34760, TSA1_YEAST;  Q04120, TSA2_YEAST;  P57279, TSAA_BUCAI;  
Q8K9W0, TSAA_BUCAP;  Q89AS1, TSAA_BUCBP;  P56876, TSAA_HELPJ;  
P21762, TSAA_HELPY;  P52570, TSA_ONCVO;  P73728, Y1621_SYNY3;  
P9WIE2, Y2238_MYCTO;  P9WIE3, Y2238_MYCTU;  P65689, Y2262_MYCBO;  
Q53212, Y4VD_RHISN;  Q55624, Y755_SYNY3;  P49537, YCF42_ODOSI;  
P51272, YCF42_PORPU;  Q1XDL4, YCF42_PYRYE;  P26830, YNDH_BACYN;  
O69777, YRP2_RHIET;  

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