ID   1.11.1.15
DE   Peroxiredoxin.
AN   AhpC.
AN   Alkyl hydroperoxide reductase C22.
AN   PRDX.
AN   Prx.
AN   Thioredoxin peroxidase.
AN   TrxPx.
AN   Tryparedoxin peroxidase.
AN   TXNPx.
CA   2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
CC   -!- Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant
CC       proteins.
CC   -!- They can be divided into three classes: typical 2-Cys, atypical 2-Cys
CC       and 1-Cys peroxiredoxins.
CC   -!- The peroxidase reaction comprises two steps centered around a redox-
CC       active cysteine called the peroxidatic cysteine.
CC   -!- All three peroxiredoxin classes have the first step in common,
CC       in which the peroxidatic cysteine attacks the peroxide substrate and
CC       is oxidized to S-hydroxycysteine (a sulfenic acid).
CC   -!- The second step of the peroxidase reaction, the regeneration of
CC       cysteine from S-hydroxycysteine, distinguishes the three
CC       peroxiredoxin classes.
CC   -!- For typical 2-Cys Prxs, in the second step, the peroxidatic
CC       S-hydroxycysteine from one subunit is attacked by the 'resolving'
CC       cysteine located in the C-terminus of the second subunit, to form an
CC       intersubunit disulfide bond, which is then reduced by one of several
CC       cell-specific thiol-containing reductants (R'-SH) (e.g. thioredoxin,
CC       AhpF, tryparedoxin or AhpD), completing the catalytic cycle.
CC   -!- In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its
CC       resolving cysteine are in the same polypeptide, so their reaction
CC       forms an intrachain disulfide bond.
CC   -!- To recycle the disulfide, known atypical 2-Cys Prxs appear to use
CC       thioredoxin as an electron donor.
CC   -!- The 1-Cys Prxs conserve only the peroxidatic cysteine, so that its
CC       oxidized form is directly reduced to cysteine by the reductant
CC       molecule.
DR   O17433, 1CPX_DIRIM ;  P38013, AHP1_YEAST ;  P82954, AHPC_ACICA ;
DR   P80239, AHPC_BACSU ;  P83117, AHPC_DELAC ;  P0AE10, AHPC_ECO57 ;
DR   P0AE09, AHPC_ECOL6 ;  P0AE08, AHPC_ECOLI ;  A0R1V9, AHPC_MYCS2 ;
DR   Q7BHK8, AHPC_MYCTU ;  P72314, AHPC_RHORU ;  P0A252, AHPC_SALTI ;
DR   P0A251, AHPC_SALTY ;  P0AE11, AHPC_SHIFL ;  Q2FJN4, AHPC_STAA3 ;
DR   P0A0B7, AHPC_STAA8 ;  Q2YVK2, AHPC_STAAB ;  Q5HIR5, AHPC_STAAC ;
DR   P0A0B5, AHPC_STAAM ;  P99074, AHPC_STAAN ;  Q6GJR7, AHPC_STAAR ;
DR   Q6GC91, AHPC_STAAS ;  P0A0B6, AHPC_STAAW ;  Q5HRY1, AHPC_STAEQ ;
DR   Q8CMQ2, AHPC_STAES ;  Q4L376, AHPC_STAHJ ;  Q49UT8, AHPC_STAS1 ;
DR   C1F4K1, AHPD_ACIC5 ;  B8J9Z2, AHPD_ANAD2 ;  Q2IMQ8, AHPD_ANADE ;
DR   A7HCA3, AHPD_ANADF ;  B4UA87, AHPD_ANASK ;  A8HQP5, AHPD_AZOC5 ;
DR   B2IHZ4, AHPD_BEII9 ;  Q9ANL0, AHPD_BRAJA ;  A5ENR3, AHPD_BRASB ;
DR   A4YYT0, AHPD_BRASO ;  B2SAW2, AHPD_BRUA1 ;  Q2YKW2, AHPD_BRUA2 ;
DR   Q578J2, AHPD_BRUAB ;  A9MBZ4, AHPD_BRUC2 ;  Q8YCF2, AHPD_BRUME ;
DR   A9WZ04, AHPD_BRUSI ;  Q8FVW4, AHPD_BRUSU ;  B8GVX4, AHPD_CAUCN ;
DR   Q9A268, AHPD_CAUCR ;  C3PGV9, AHPD_CORA7 ;  Q6NGT4, AHPD_CORDI ;
DR   C4LJ26, AHPD_CORK4 ;  B6IZ19, AHPD_COXB2 ;  A9KBI4, AHPD_COXBN ;
DR   A9N917, AHPD_COXBR ;  Q83BM5, AHPD_COXBU ;  Q0RH96, AHPD_FRAAA ;
DR   A8L1J2, AHPD_FRASN ;  A9H8D2, AHPD_GLUDA ;  Q0BUC5, AHPD_GRABC ;
DR   Q0BXT2, AHPD_HYPNA ;  Q1IJ49, AHPD_KORVE ;  Q0AKM4, AHPD_MARMM ;
DR   B0UAJ8, AHPD_METS4 ;  B8EJZ2, AHPD_METSB ;  A0QGI9, AHPD_MYCA1 ;
DR   B1MJX0, AHPD_MYCA9 ;  P0A5N5, AHPD_MYCBO ;  A1KLC4, AHPD_MYCBP ;
DR   C1AQZ5, AHPD_MYCBT ;  B2HD59, AHPD_MYCMM ;  Q73ZL4, AHPD_MYCPA ;
DR   Q50441, AHPD_MYCS2 ;  A5U5C5, AHPD_MYCTA ;  P0A5N4, AHPD_MYCTU ;
DR   A0PSD4, AHPD_MYCUA ;  Q5YT53, AHPD_NOCFA ;  A6X5N3, AHPD_OCHA4 ;
DR   B6IQZ3, AHPD_RHOCS ;  C0ZYQ9, AHPD_RHOE4 ;  Q07I00, AHPD_RHOP5 ;
DR   Q20Y19, AHPD_RHOPB ;  Q02BZ5, AHPD_SOLUE ;  A5VCB6, AHPD_SPHWW ;
DR   Q82IC5, AHPD_STRAW ;  Q7AKI6, AHPD_STRCO ;  B1W2G7, AHPD_STRGG ;
DR   Q9X5V1, AHPD_STRVD ;  Q96291, BAS1A_ARATH;  Q9C5R8, BAS1B_ARATH;
DR   Q96468, BAS1_HORVU ;  Q6ER94, BAS1_ORYSJ ;  P84729, BAS1_PINST ;
DR   O24364, BAS1_SPIOL ;  P80602, BAS1_WHEAT ;  O53911, BCPB_MYCTU ;
DR   Q796Y8, BCP_BACSU  ;  Q9ZHF0, BCP_BUCAP  ;  Q83CY8, BCP_COXBU  ;
DR   P0AE54, BCP_ECO57  ;  P0AE53, BCP_ECOL6  ;  P0AE52, BCP_ECOLI  ;
DR   P44411, BCP_HAEIN  ;  Q9ZMU4, BCP_HELPJ  ;  P55979, BCP_HELPY  ;
DR   O53226, BCP_MYCTU  ;  P0AE55, BCP_SHIFL  ;  P19476, CR29_ENTHI ;
DR   P40553, DOT5_YEAST ;  P40581, GPX3_YEAST ;  P56577, MALF2_MALFU;
DR   P56578, MALF3_MALFU;  P0C0L2, OSMC_ECOLI ;  P0C0L3, OSMC_SHIFL ;
DR   Q9MB35, PERQ_SEDLI ;  Q6UBI3, PERQ_SUASA ;  O43099, PMP20_ASPFU;
DR   Q5ASN8, PMP20_EMENI;  Q01116, PMP20_LIPKO;  O14313, PMP20_SCHPO;
DR   P14292, PMPA_CANBO ;  P14293, PMPB_CANBO ;  Q69TY4, PR2E1_ORYSJ;
DR   Q7F8S5, PR2E2_ORYSJ;  Q5E947, PRDX1_BOVIN;  P0CB50, PRDX1_CHICK;
DR   Q9JKY1, PRDX1_CRIGR;  Q9V3P0, PRDX1_DROME;  Q6DV14, PRDX1_GECJA;
DR   Q06830, PRDX1_HUMAN;  P35700, PRDX1_MOUSE;  Q6B4U9, PRDX1_MYOLU;
DR   Q63716, PRDX1_RAT  ;  Q9BGI3, PRDX2_BOVIN;  Q8K3U7, PRDX2_CRIGR;
DR   P32119, PRDX2_HUMAN;  Q2PFZ3, PRDX2_MACFA;  Q61171, PRDX2_MOUSE;
DR   P52552, PRDX2_PIG  ;  Q5RC63, PRDX2_PONAB;  P35704, PRDX2_RAT  ;
DR   P35705, PRDX3_BOVIN;  P30048, PRDX3_HUMAN;  P20108, PRDX3_MOUSE;
DR   Q5REY3, PRDX3_PONAB;  Q9Z0V6, PRDX3_RAT  ;  Q9BGI2, PRDX4_BOVIN;
DR   P0CV91, PRDX4_CROAT;  Q555L5, PRDX4_DICDI;  Q13162, PRDX4_HUMAN;
DR   O08807, PRDX4_MOUSE;  Q9Z0V5, PRDX4_RAT  ;  Q9BGI1, PRDX5_BOVIN;
DR   Q9GLW7, PRDX5_CHLAE;  P30044, PRDX5_HUMAN;  P86241, PRDX5_MESAU;
DR   P99029, PRDX5_MOUSE;  Q9GLW9, PRDX5_PAPHA;  Q9R063, PRDX5_RAT  ;
DR   P83200, PRDX5_VULVU;  O77834, PRDX6_BOVIN;  Q5ZJF4, PRDX6_CHICK;
DR   P30041, PRDX6_HUMAN;  Q2PFL9, PRDX6_MACFA;  P86215, PRDX6_MESAU;
DR   O08709, PRDX6_MOUSE;  Q9TSX9, PRDX6_PIG  ;  Q5R7E0, PRDX6_PONAB;
DR   O35244, PRDX6_RAT  ;  Q9NL98, PRDX_ASCSU ;  P34227, PRX1_YEAST ;
DR   Q7G959, PRX2A_ARATH;  Q9XEX2, PRX2B_ARATH;  Q9SRZ4, PRX2C_ARATH;
DR   Q9FR35, PRX2C_ORYSJ;  O22711, PRX2D_ARATH;  Q949U7, PRX2E_ARATH;
DR   Q9M7T0, PRX2F_ARATH;  Q9SDD6, PRX2F_ORYSJ;  P44758, PRX5_HAEIN ;
DR   Q9LU86, PRXQ_ARATH ;  Q75SY5, PRXQ_GENTR ;  P0C5D4, PRXQ_ORYSI ;
DR   P0C5D5, PRXQ_ORYSJ ;  Q6QPJ6, PRXQ_POPJC ;  Q5S1S6, PRXQ_WHEAT ;
DR   Q9L3Q5, PRXU_EUBAC ;  O94561, PRX_SCHPO  ;  P23161, R20K_CLOPA ;
DR   P0C5C8, REHYA_ORYSI;  P0C5C9, REHYA_ORYSJ;  P0C5D0, REHYB_ORYSI;
DR   P0C5D1, REHYB_ORYSJ;  O04005, REHY_ARATH ;  P52571, REHY_BROSE ;
DR   P52572, REHY_HORVU ;  A2SZW8, REHY_MAIZE ;  Q6E2Z6, REHY_MEDTR ;
DR   P52574, REHY_TORRU ;  Q6W8Q2, REHY_WHEAT ;  P48822, TDX1_BRUMA ;
DR   Q21824, TDX1_CAEEL ;  Q17172, TDX2_BRUMA ;  Q6L240, TDXH1_PICTO;
DR   Q55060, TDXH1_SULME;  Q974S8, TDXH1_SULTO;  Q9HKX0, TDXH1_THEAC;
DR   Q8RCY5, TDXH1_THETN;  Q6L140, TDXH2_PICTO;  O33665, TDXH2_SULME;
DR   Q96XS5, TDXH2_SULTO;  Q9HJL3, TDXH2_THEAC;  Q8R844, TDXH2_THETN;
DR   Q9Y9L0, TDXH_AERPE ;  O67024, TDXH_AQUAE ;  O29969, TDXH_ARCFU ;
DR   Q8KBN8, TDXH_CHLTE ;  A2BJD9, TDXH_HYPBU ;  A8A9P0, TDXH_IGNH4 ;
DR   Q58146, TDXH_METJA ;  A4FWZ9, TDXH_METM5 ;  Q8PYP6, TDXH_METMA ;
DR   Q6LY19, TDXH_METMP ;  O26262, TDXH_METTH ;  Q57109, TDXH_METTM ;
DR   A6UPH7, TDXH_METVS ;  Q74NC6, TDXH_NANEQ ;  Q9UZV4, TDXH_PYRAB ;
DR   Q8U218, TDXH_PYRFU ;  O58966, TDXH_PYRHO ;  Q5JF30, TDXH_PYRKO ;
DR   A3DKL1, TDXH_STAMF ;  P95895, TDXH_SULSO ;  Q9WZR4, TDXH_THEMA ;
DR   A5IIX7, TDXH_THEP1 ;  Q979N7, TDXH_THEVO ;  Q73RS4, TDXH_TREDE ;
DR   Q90384, TDX_CYNPY  ;  Q8T6C4, TDX_ECHGR  ;  Q8SS85, TDX_ENCCU  ;
DR   P91883, TDX_FASHE  ;  Q91191, TDX_ONCMY  ;  Q26695, TDX_TRYBR  ;
DR   Q9Y7F0, TSA1_CANAL ;  O74887, TSA1_SCHPO ;  P34760, TSA1_YEAST ;
DR   Q04120, TSA2_YEAST ;  P57279, TSAA_BUCAI ;  Q8K9W0, TSAA_BUCAP ;
DR   Q89AS1, TSAA_BUCBP ;  P56876, TSAA_HELPJ ;  P21762, TSAA_HELPY ;
DR   P52570, TSA_ONCVO  ;  P73728, Y1621_SYNY3;  P65688, Y2238_MYCTU;
DR   P65689, Y2262_MYCBO;  Q53212, Y4VD_RHISN ;  Q55624, Y755_SYNY3 ;
DR   P49537, YCF42_ODOSI;  P51272, YCF42_PORPU;  Q1XDL4, YCF42_PORYE;
DR   P26830, YNDH_BACYN ;  O69777, YRP2_RHIET ;
//