ENZYME entry: EC 1.11.1.23

Accepted Name
(S)-2-hydroxypropylphosphonic acid epoxidase.
Alternative Name(s)
(S)-2-hydroxypropylphosphonate epoxidase.
2-hydroxypropylphosphonic acid epoxidase.
HPP epoxidase.
Reaction catalysed
(S)-2-hydroxypropylphosphonate + H(2)O(2) <=> (1R,2S)-1,2-epoxypropylphosphonate + 2 H(2)O
Cofactor(s)
Fe cation.
Comment(s)
  • This is the last enzyme in the biosynthetic pathway of fosfomycin, a broad-spectrum antibiotic produced by certain Streptomyces species.
  • Contains non heme iron that forms a iron(IV)-oxo (ferryl) complex with hydrogen peroxide, which functions as a proton abstractor from the substrate.
  • Formerly EC 1.14.19.7.
Cross-references
BRENDA1.11.1.23
EC2PDB1.11.1.23
ExplorEnz1.11.1.23
PRIAM enzyme-specific profiles1.11.1.23
KEGG Ligand Database for Enzyme Nomenclature1.11.1.23
IUBMB Enzyme Nomenclature1.11.1.23
IntEnz1.11.1.23
MEDLINEFind literature relating to 1.11.1.23
MetaCyc1.11.1.23
UniProtKB/Swiss-Prot
Q9JN69, HPPE_PSESX;  Q56185, HPPE_STRWE;  

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