ID 1.11.1.8 DE iodide peroxidase. AN iodinase. AN thyroid peroxidase. AN thyroperoxidase. AN TPO. CA (1) 2 H(+) + H2O2 + 2 iodide = diiodine + 2 H2O. CA (2) [thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide = [thyroglobulin]- CA 3-iodo-L-tyrosine + 2 H2O. CA (3) [thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide = CA [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O. CA (4) 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]- CA dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O. CA (5) [thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L- CA tyrosine + H2O2 = [thyroglobulin]-3,3',5-triiodo-L-thyronine + CA [thyroglobulin]-dehydroalanine + 2 H2O. CC -!- Thyroid peroxidase catalyzes the biosynthesis of the thyroid hormones CC L-thyroxine and triiodo-L-thyronine. CC -!- It catalyzes both the iodination of tyrosine residues in CC thyroglobulin (forming mono- and di-iodinated forms) and their CC coupling to form either L-thyroxine or triiodo-L-thyronine. DR Q8HYB7, PERT_CANLF ; P07202, PERT_HUMAN ; P35419, PERT_MOUSE ; DR P09933, PERT_PIG ; P14650, PERT_RAT ; //