ENZYME

ENZYME entry: EC 1.11.2.1

Accepted Name

Unspecific peroxygenase.

Alternative Name(s)

Haloperoxidase-peroxygenase.

Reaction catalysed

RH + H(2)O(2) <=> ROH + H(2)O

Cofactor(s)

Heme-thiolate.

Comment(s)

Enzymes of this type include glycoproteins secreted by agaric basidiomycetes.
They catalyze the insertion of an oxygen atom from H(2)O(2) into a wide variety of substrates, including aromatic rings such as naphthalene, toluene, phenanthrene, pyrene and p-nitrophenol, recalcitrant heterocycles such as pyridine, dibenzofuran, various ethers (resulting in O-dealkylation) and alkanes such as propane, hexane and cyclohexane.
Reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, O- and N-dealkylation, bromination and one-electron oxidations.
They have little or no activity toward chloride.
Mechanistically, the catalytic cycle of unspecific (mono)- peroxygenases combines elements of the 'shunt' pathway of cytochrome P450s (a side activity that utilizes a peroxide in place of dioxygen and NAD(P)H) and the classic heme peroxidase cycle.

Cross-references

PROSITE

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature