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ENZYME entry: EC 1.11.2.2

Accepted Name
Myeloperoxidase.
Alternative Name(s)
MPO.
Verdoperoxidase.
Reaction catalysed
Cl(-) + H(2)O(2) + H(+) <=> HClO + H(2)O
Cofactor(s)
Ca(2+); Heme.
Comment(s)
  • Is present in phagosomes of neutrophils and monocytes, where the hypochlorite produced is strongly bactericidal.
  • It differs from EC 1.11.1.10 in its preference for formation of hypochlorite over the chlorination of organic substrates under physiological conditions (pH 5-8).
  • Hypochlorite in turn forms a number of antimicrobial products (Cl(2), chloramines, hydroxyl radical, singlet oxygen).
  • MPO also oxidizes bromide, iodide and thiocyanate.
  • In the absence of halides, it oxidizes phenols and has a moderate peroxygenase activity toward styrene.
Cross-references
PROSITEPDOC00394
BRENDA1.11.2.2
EC2PDB1.11.2.2
ExplorEnz1.11.2.2
PRIAM enzyme-specific profiles1.11.2.2
KEGG Ligand Database for Enzyme Nomenclature1.11.2.2
IUBMB Enzyme Nomenclature1.11.2.2
IntEnz1.11.2.2
MEDLINEFind literature relating to 1.11.2.2
MetaCyc1.11.2.2
UniProtKB/Swiss-Prot
P05164, PERM_HUMAN;  P11247, PERM_MOUSE;  

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