ID   1.11.2.2
DE   myeloperoxidase.
AN   MPO.
AN   verdoperoxidase.
CA   chloride + H(+) + H2O2 = H2O + hypochlorous acid.
CC   -!- Is present in phagosomes of neutrophils and monocytes, where the
CC       hypochlorite produced is strongly bactericidal.
CC   -!- It differs from EC 1.11.1.10 in its preference for formation of
CC       hypochlorite over the chlorination of organic substrates under
CC       physiological conditions (pH 5-8).
CC   -!- Hypochlorite in turn forms a number of antimicrobial products (Cl2,
CC       chloramines, hydroxyl radical, singlet oxygen).
CC   -!- MPO also oxidizes bromide, iodide and thiocyanate.
CC   -!- In the absence of halides, it oxidizes phenols and has a moderate
CC       peroxygenase activity toward styrene.
DR   P05164, PERM_HUMAN ;  P11247, PERM_MOUSE ;
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