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ENZYME entry: EC 1.12.1.5

Accepted Name
Hydrogen dehydrogenase (NAD(P)(+)).
Reaction catalysed
H(2) + NAD(P)(+) <=> H(+) + NAD(P)H
Cofactor(s)
Fe cation; Iron-sulfur; Ni(2+).
Comment(s)
  • The enzyme from the archaeon Pyrococcus furiosus is part of a heterotetrameric complex where the alpha and delta subunits function as a hydrogenase while the beta and gamma subunits function as sulfur reductase (EC 1.12.98.4).
  • Different from EC 1.12.1.3.
Cross-references
BRENDA1.12.1.5
EC2PDB1.12.1.5
ExplorEnz1.12.1.5
PRIAM enzyme-specific profiles1.12.1.5
KEGG Ligand Database for Enzyme Nomenclature1.12.1.5
IUBMB Enzyme Nomenclature1.12.1.5
IntEnz1.12.1.5
MEDLINEFind literature relating to 1.12.1.5
MetaCyc1.12.1.5
UniProtKB/Swiss-Prot
E7FHC4, HYD2A_PYRFU;  E7FHF8, HYD2D_PYRFU;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.12.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.12.-.-
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