ENZYME entry: EC 1.12.2.1

Accepted Name
Cytochrome-c3 hydrogenase.
Alternative Name(s)
Cytochrome c3 reductase.
Cytochrome hydrogenase.
H(2):ferricytochrome c3 oxidoreductase.
Reaction catalysed
2 H(2) + ferricytochrome c3 <=> 4 H(+) + ferrocytochrome c3
Cofactor(s)
Iron-sulfur; Ni(2+).
Comment(s)
  • Some forms of the enzyme contain nickel ([NiFe]-hydrogenases) and, of these, some contain selenocysteine ([NiFeSe]-hydrogenases).
  • Methylene blue and other acceptors can also be reduced.
Cross-references
BRENDA1.12.2.1
EC2PDB1.12.2.1
ExplorEnz1.12.2.1
PRIAM enzyme-specific profiles1.12.2.1
KEGG Ligand Database for Enzyme Nomenclature1.12.2.1
IUBMB Enzyme Nomenclature1.12.2.1
IntEnz1.12.2.1
MEDLINEFind literature relating to 1.12.2.1
MetaCyc1.12.2.1
UniProtKB/Swiss-Prot
P80509, HC3L_ACIFR;  P80510, HC3S_ACIFR;  P18188, PHNL_DESFR;  
P12944, PHNL_DESGI;  P21852, PHNL_DESVM;  Q06173, PHNS1_DESVH;  
P61429, PHNS2_DESVH;  P13061, PHNS_DESDA;  P18187, PHNS_DESFR;  
P12943, PHNS_DESGI;  P13062, PHNS_DESMU;  P21853, PHNS_DESVM;  

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