ENZYME entry: EC 1.13.11.31

Accepted Name
Arachidonate 12-lipoxygenase.
Alternative Name(s)
12-lipoxygenase.
Reaction catalysed
Arachidonate + O(2) <=> (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
Cofactor(s)
Fe cation.
Comment(s)
The product is rapidly reduced to the corresponding 12S-hydroxy compound.
Cross-references
PROSITEPDOC00077
BRENDA1.13.11.31
EC2PDB1.13.11.31
ExplorEnz1.13.11.31
PRIAM enzyme-specific profiles1.13.11.31
KEGG Ligand Database for Enzyme Nomenclature1.13.11.31
IUBMB Enzyme Nomenclature1.13.11.31
IntEnz1.13.11.31
MEDLINEFind literature relating to 1.13.11.31
MetaCyc1.13.11.31
UniProtKB/Swiss-Prot
P18054, LOX12_HUMAN;  P39655, LOX12_MOUSE;  F1LQ70, LOX12_RAT;  
P27479, LOX15_BOVIN;  P16050, LOX15_HUMAN;  P39654, LOX15_MOUSE;  
P16469, LOX15_PIG;  Q5RBE8, LOX15_PONAB;  P12530, LOX15_RABIT;  
Q02759, LOX15_RAT;  P55249, LX12E_MOUSE;  D3ZQF9, LX12E_RAT;  

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