ID 1.13.11.52 DE indoleamine 2,3-dioxygenase. AN IDO. AN tryptophan pyrrolase. CA (1) D-tryptophan + O2 = N-formyl-D-kynurenine. CA (2) L-tryptophan + O2 = N-formyl-L-kynurenine. CC -!- Requires ascorbic acid and methylene blue for activity. CC -!- Has broader substrate specificity than EC 1.13.11.11. CC -!- Is induced in response to pathological conditions and host-defense CC mechanisms. CC -!- While the enzyme is more active with D-tryptophan than L-tryptophan, CC its only known function to date is in the metabolism of L-tryptophan. CC -!- Superoxide radicals can replace O2 as oxygen donor. DR A0A2I2F272, ACDA_ASPCN ; P14902, I23O1_HUMAN; P28776, I23O1_MOUSE; DR Q9ERD9, I23O1_RAT ; P47125, I23O_YEAST ; A0A6G9KIF9, NANC_ASPNN ; DR P0DUR8, QULI_PENCI ; Q0CG33, TPZB_ASPTN ; //