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ENZYME entry: EC 1.13.11.58

Accepted Name
Linoleate 9S-lipoxygenase.
Alternative Name(s)
9-lipoxygenase.
9S-lipoxygenase.
Linoleate 9-lipoxygenase.
Reaction catalysed
Linoleate + O(2) <=> (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
Cofactor(s)
Fe cation.
Comment(s)
  • A common plant lipoxygenase that oxidizes linoleate and alpha- linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C(9) position with (S)- configuration.
  • The enzyme plays a physiological role during the early stages of seedling growth.
  • The enzyme from Arabidopsis thaliana shows comparable activity toward linoleate and linolenate.
  • EC 1.13.11.12 catalyzes a similar reaction at another position of these fatty acids.
Cross-references
BRENDA1.13.11.58
EC2PDB1.13.11.58
ExplorEnz1.13.11.58
PRIAM enzyme-specific profiles1.13.11.58
KEGG Ligand Database for Enzyme Nomenclature1.13.11.58
IUBMB Enzyme Nomenclature1.13.11.58
IntEnz1.13.11.58
MEDLINEFind literature relating to 1.13.11.58
MetaCyc1.13.11.58
UniProtKB/Swiss-Prot
P37831, LOX11_SOLTU;  O24379, LOX12_SOLTU;  Q43189, LOX13_SOLTU;  
Q43190, LOX14_SOLTU;  Q43191, LOX15_SOLTU;  Q41238, LOX16_SOLTU;  
O22507, LOX17_SOLTU;  O22508, LOX18_SOLTU;  Q06327, LOX1_ARATH;  
P29114, LOX1_HORVU;  P38414, LOX1_LENCU;  Q76I22, LOX1_ORYSJ;  
P29250, LOX2_ORYSJ;  P14856, LOX2_PEA;  P09439, LOX2_SOYBN;  
Q7G794, LOX3_ORYSJ;  P09918, LOX3_PEA;  P09186, LOX3_SOYBN;  
Q53RB0, LOX4_ORYSJ;  P38417, LOX4_SOYBN;  Q9LUW0, LOX5_ARATH;  
P27480, LOXA_PHAVU;  P38415, LOXA_SOLLC;  P27481, LOXB_PHAVU;  
P38416, LOXB_SOLLC;  P24095, LOXX_SOYBN;  Q8RNT4, LOX_PSEAI;  
T0JRM4, MNLOX_COLGC;  G4NAP4, MNLOX_MAGO7;  P0CT92, MNLOX_NAKOS;  

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