ID   1.13.11.65
DE   carotenoid isomerooxygenase.
CA   all-trans-zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-
CA   trans-3-hydroxyretinal.
CC   -!- The enzyme, characterized from the moth Galleria mellonella and the
CC       fruit fly Drosophila melanogaster, is involved in the synthesis of
CC       retinal from dietary caroteoids in insects.
CC   -!- The enzyme accepts different all-trans carotenoids, including beta-
CC       carotene, alpha-carotene and lutein, and catalyzes the symmetrical
CC       cleavage of the carotenoid and the simultaneous isomerization of only
CC       one of the products to a cis configuration.
CC   -!- When the substrate is hydroxylated only in one side (as in
CC       cryptoxanthin), the enzyme preferentially isomerizes the hydroxylated
CC       part of the molecule.
CC   -!- Formerly EC 1.14.13.164.
DR   Q9VFS2, NINAB_DROME;  A8Y9I2, NINAB_GALME;
//