ENZYME entry: EC 1.13.11.74

Accepted Name
2-aminophenol 1,6-dioxygenase.
Reaction catalysed
2-aminophenol + O(2) <=> 2-aminomuconate 6-semialdehyde
Cofactor(s)
Fe(2+).
Comment(s)
  • The enzyme, is an extradiol-type dioxygenase that utilizes a non-heme ferrous iron to cleave the aromatic ring at the meta position (relative to the hydroxyl substituent).
  • The enzyme also has some activity with 2-amino-5-methylphenol and 2-amino-4-methylphenol.
  • The enzyme from the bacterium Comamonas testosteroni CNB-1 also has the activity of EC 1.13.11.76.
  • Formerly EC 1.13.11.n1.
Cross-references
BRENDA1.13.11.74
EC2PDB1.13.11.74
ExplorEnz1.13.11.74
PRIAM enzyme-specific profiles1.13.11.74
KEGG Ligand Database for Enzyme Nomenclature1.13.11.74
IUBMB Enzyme Nomenclature1.13.11.74
IntEnz1.13.11.74
MEDLINEFind literature relating to 1.13.11.74
MetaCyc1.13.11.74
UniProtKB/Swiss-Prot
Q6J1Z6, AMNB_COMTE;  O33477, AMNB_PSESP;  

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