Expasy logo

ENZYME

ENZYME entry: EC 1.13.11.79

PURL: https://purl.expasy.org/enzyme/EC/1.13.11.79
Accepted Name
aerobic 5,6-dimethylbenzimidazole synthase
Alternative Name(s)
flavin reductase
Reaction catalysed
FMNH2 + O2 = dialurate + 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + H(+)
Comment(s)
  • The enzyme catalyzes a complex oxygen-dependent conversion of reduced flavin mononucleotide to form 5,6-dimethylbenzimidazole, the lower ligand of vitamin B12.
  • This conversion involves many sequential steps in two distinct stages, and an alloxan intermediate that acts as a proton donor, a proton acceptor, and a hydride acceptor.
  • The C-2 of 5,6-dimethylbenzimidazole is derived from C-1' of the ribityl group of FMNH2 and 2-H from the ribityl 1'-pro-S hydrogen.
  • While D-erythrose 4-phosphate has been shown to be one of the by-products, the nature of the other product(s) has not been verified yet.
  • Formerly EC 1.14.99.40.
Cross-references
Rhea expert-curated reactions1.13.11.79
ExplorEnz1.13.11.79
IUBMB Enzyme Nomenclature1.13.11.79
UniProtKB/Swiss-Prot
Q92PC8, BLUB_RHIMEP0CY55, BLUB_RHOCAD5AV14, BLUB_RHOCB
Q2RNG5, BLUB_RHORT
BRENDA1.13.11.79
MetaCyc1.13.11.79
KEGG Ligand Database for Enzyme Nomenclature1.13.11.79
EC2PDB1.13.11.79
MEDLINEFind literature relating to 1.13.11.79

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.13.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.13.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-