ENZYME entry: EC 1.13.11.79

Accepted Name
5,6-dimethylbenzimidazole synthase.
Reaction catalysed
FMNH(2) + NADH + O(2) <=> 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD(+) + other product(s)
Comment(s)
  • The enzyme catalyzes a complex oxygen-dependent conversion of reduced flavin mononucleotide to form 5,6-dimethylbenzimidazole, the lower ligand of vitamin B12.
  • This conversion involves many sequential steps in two distinct stages, and an alloxan intermediate that acts as a proton donor, a proton acceptor, and a hydride acceptor.
  • The C-2 of 5,6-dimethylbenzimidazole is derived from C-1' of the ribityl group of FMNH(2) and 2-H from the ribityl 1'-pro-S hydrogen.
  • While D-erythrose 4-phosphate has been shown to be one of the byproducts, the nature of the other product(s) has not been verified yet.
  • Formerly EC 1.14.99.40.
Cross-references
BRENDA1.13.11.79
EC2PDB1.13.11.79
ExplorEnz1.13.11.79
PRIAM enzyme-specific profiles1.13.11.79
KEGG Ligand Database for Enzyme Nomenclature1.13.11.79
IUBMB Enzyme Nomenclature1.13.11.79
IntEnz1.13.11.79
MEDLINEFind literature relating to 1.13.11.79
MetaCyc1.13.11.79
UniProtKB/Swiss-Prot
Q92PC8, BLUB_RHIME;  P0CY55, BLUB_RHOCA;  D5AV14, BLUB_RHOCB;  
Q2RNG5, BLUB_RHORT;  

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