ENZYME entry: EC 1.13.12.15

Accepted Name
3,4-dihydroxyphenylalanine oxidative deaminase.
Alternative Name(s)
DOPA oxidative deaminase.
DOPAODA.
Oxidative deaminase.
Reaction catalysed
2 L-dopa + O(2) <=> 2 3,4-dihydroxyphenylpyruvate + 2 NH(3)
Comment(s)
  • One of the three enzymes involved in L-dopa (3,4- dihydroxyphenylalanine) catabolism in the non-oxygenic phototrophic bacterium Rubrivivax benzoatilyticus OU5 (and not Rhodobacter sphaeroides OU5 as had been thought), the other two being EC 4.3.1.22 and EC 2.6.1.49.
  • In addition to DOPA, the enzyme can also use L-tyrosine, L-phenylalanine, L-tryptophan and glutamate as substrate, but more slowly.
  • Inhibited by NADH and 2-oxoglutarate.
Cross-references
BRENDA1.13.12.15
EC2PDB1.13.12.15
ExplorEnz1.13.12.15
PRIAM enzyme-specific profiles1.13.12.15
KEGG Ligand Database for Enzyme Nomenclature1.13.12.15
IUBMB Enzyme Nomenclature1.13.12.15
IntEnz1.13.12.15
MEDLINEFind literature relating to 1.13.12.15
MetaCyc1.13.12.15

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