ID 1.13.12.17 DE dichloroarcyriaflavin A synthase. CA dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 = 2 CO2 + CA dichloroarcyriaflavin A + 6 H2O + 4 NAD(+). CC -!- The conversion of dichlorochromopyrrolate to dichloroarcyriaflavin A CC is a complex process that involves two enzyme components. CC -!- RebP is an NAD-dependent cytochrome P450 oxygenase that performs an CC aryl-aryl bond formation yielding the six-ring indolocarbazole CC scaffold. CC -!- Along with RebC, a flavin-dependent hydroxylase, it also catalyzes CC the oxidative decarboxylation of both carboxyl groups. CC -!- The presence of RebC ensures that the only product is the CC rebeccamycin aglycone dichloroarcyriaflavin A. CC -!- The enzymes are similar, but not identical, to StaP and StaC, which CC are involved in the synthesis of staurosporine. //